摘要
目的探讨TCT技术和TBS方案应用于宫颈病变筛查的可靠性。方法收集我院妇科门诊4629例宫颈液基细胞学标本，采用TBS方案诊断，对170例细胞学阳性片行阴道镜及活检诊断，并对其发病年龄进行分析。结果TCT检出100％（4／4）的鳞状细胞癌（SCC），检出94％（47／50）的鳞状上皮内高度病变（HSIL），78．8％（41／52）的鳞状上皮内低度病变（LSIL）。经X^2检验，液基细胞学对HSII．与阴道镜活检，病理组织学诊断的符合率显著高于LSII，（P＜0．05）。细胞学阳性患者年龄分布主要发生于25-50岁年龄段，特别是35-40岁组发生率最高，达30．59％。结论TCT技术和TBS方案对宫颈病变的筛查具有良好的实用性，对宫颈上皮内瘤变，特别是对HSIL及以上的病变敏感性高。25～50岁年龄段妇女应定期做TCT筛查，对35～40岁组应做重点筛查。
Objective To investigate the reliability of Thinprep cytologic test（TCT） technique and the Bethesda System（TBS） project in screening of cervical pathological changes. Methods 4629 cervical liquid based cytology samples were collected in this study and diagnosed by TBS project. 170 cytology positive cases were compared by colposcopical examination and biopsy and their age of onset were analysed. Results By TCT technique, 100%（4/4） squamous carcinoma of the cervix（SCC）, 94%（47/50） high grade squamous intraepithelial lesion（HSIL）, 78.8% （41/52） low grade squamous intraepithelial lesion（LSIL） were detected. Chi square test displayed the diagnosis coincidence of HSIL greater than that of LSIL significantly among liquid based cytology, colposcopical biopsy and pathologic histology （P〈0.05）. The age distribution of cytology positive cases always betided in 25-50 age stage, especially in 35-40 age stage, incidence was topmost , and reached up to 30.59%. Conclusion The TCT technique and TBS project have satisfactory applicability for screening cervical pathological changes, and have high sensitive for cervical intraepithelial neoplasia（CIN） ,especially for HSIL pathological changes and grades above it. It is necessary for women of 25-50 age stage to screen by TCT regularly, emphasis on 35-40 age stage.
出处
《重庆医学》
CAS
CSCD
2006年第13期1195-1196,共2页
Chongqing medicine
关键词
液基细胞学
宫颈肿瘤
TBS
筛查
liquid based cytology
cervical neoplasia,the Bethesda system（TBS）
screen
