摘要
肺动脉高压(PH)是以肺小血管收缩、重构和原位血栓形成为病理特征的临床血流动力学症候群,表现为肺动脉压力和肺血管阻力升高。内皮素、一氧化氮和前列环素通路失衡在PH病理发生中发挥重要作用。针对调节这3个通路的现代治疗方法与过去常规治疗方法综合应用可明显延长PH患者寿命,并提高其生活质量。
Pulmonary hypertension（PH） is a clinical hemodynamic syndrome characterized by elevation of pulmonary artery pressure and pulmonary vascular resistance, which was presumed mainly due to pulmonary vasoconstriction, remodeling of the pulmonary vessel wall, and thrombosis in situ, Endothelin, nitric oxide, and prostacyclin pathway were three major pathways involved in the pathogenesis.Current therapies interfered with these 3 pathways in combination with conventional measures have prolonged length of life of patients and improved their quality of life significantly,
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第13期875-878,共4页
Journal of Applied Clinical Pediatrics
关键词
肺动脉高压
治疗
儿童
pulmonary hypertension
treatment
child
