摘要
目的观察消积饮、华蟾素联合长春瑞滨治疗体力状况(PS)评分2.0的ⅢB/Ⅳ期非小细胞肺癌的疗效和毒副反应。方法对31例患者给予消积饮、华蟾素和长春瑞滨治疗,21天为1个周期,连续治疗4个周期。观察治疗前后瘤体变化、PS评分变化、中位生存时间、1年生存率、疾病无进展时间以及毒副反应。结果治疗后的客观有效率(CR+PR)为12.9%,稳定率(CR+PR+NC)为83.8%;中位生存期(MST)为6.0个月,1年生存率为22.5%,疾病无进展时间(TTP)为4.0个月。主要毒副反应有骨髓抑制,其中Ⅳ度白细胞下降1例(3.2%);2例(6.4%)出现中度贫血;3例(9.6%)轻度周围神经毒性。结论对于PS评分2.0的ⅢB/Ⅳ期非小细胞肺癌患者,消积饮、华蟾素联合长春瑞滨的治疗方案与目前文献报道比较,显示出较好的临床疗效,且毒副反应轻,患者易于耐受。
Objective To observe the clinical effects and adverse effects of ＂Xiaoji Decoction＂, ＂Hua Chan Su＂ and Vinoreibine. in the treatment of ⅢB/Ⅳ non-small cell lung cancer with less than 2.0 PS. Methods 31 subjects were treated by above therapy for 4 cycles with 21 days in a cycle. The size of tumor,PS,median survival time,1-year survival rate,TIP and adverse effects were observed. Results After treatment,the effective rate was 12.9%,stable rate was 83.8%, median survival time was 6 months,l-year survival rate was 22.5% and TIP was 4 months;the main adverse effect was marrow suppression. Conclusion This therapy is effective for ⅢB/Ⅳ non-small cell lung cancer,with fewer adverse effects.
出处
《上海中医药杂志》
北大核心
2006年第7期30-32,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
加拿大Terryfox癌症基金资助项目
关键词
非小细胞肺癌
中西医结合疗法
消积饮
华蟾素
长春瑞滨
PS评分
＂Non-small cell lung cancer
integrative Chinese and western medicine
＂Xiaoji Decoction＂
＂Hua Chan Su＂
Vinorelbine
PS
