摘要
目的利用[11C]雷氯必利(raclopride,RAC)正电子发射体层摄影术(PET)对早期帕金森病(PD)患者的D2受体进行功能显像,了解D2受体在PD早期的变化情况。方法PD组6例,男4例,女2例,平均年龄(66.60±7.19)岁,病程为Hoehn Yahr分级l～2级。对照组4名,男2名,女2名,平均年龄(70.50±0.58)岁。PD组及对照组均进行RAC PET检查。结果[11C]RAC在尾状核和壳核显像明显,在皮质、小脑、丘脑、脑干等部位无明显显像,符合D2受体的分布特点;早期未经治疗的PD患者,在患肢对侧尾状核头、壳核前部和壳核后部,[11C]RAC的结合指数分别为2.94±0.33、3.34±0.27和3.27±0.37,明显高于对照组的2.54±0.49、2.89±0.48和2.72±0.19,差异有统计学意义(P值分别为0.046,0.013和0.022);患肢同侧尾状核头、壳核前部和壳核后部[11C]RAC的结合指数分别为2.78±0.31、3.22±0.38和3.10±0.29,也高于对照组的2.63±0.19、2.93±0.21和2.76±0.27,但未达到统计学差异;患肢同侧尾状核头、壳核前部和壳核后部[11C]RAC的结合指数分别为2.94±0.33、3.34±0.27和3.27±0.37,高于对侧相应部位的2.78±0.31、3.22±0.38和3.10±0.29,但未达到统计学差异。在对照组,双侧基底结区相应部位[11C]RAC结合指数为右侧2.54±0.49、2.89±0.48和2.72±0.19,左侧为2.63±0.19、2.93±0.21和2.76±0.27,双侧无差异;但在纹状体内的分布有区域性差异,即壳核前部[11C]RAC结合指数为2.85±0.15,壳核后部[11C]RAC结合指数为2.80±0.12,均高于尾状核的2.58±0.07,差异有统计学意义(P<0.05)。结论[11C]RAC是D2受体的特异性示踪剂,可用于活体D2受体的评价;早期未经治疗的PD患者,D2受体有上调效应。
Objective To examine the D2 receptor of early Parkinson＇ s disease with [^11C ] RAC- PET. Methods 6 PD patients,4 males,2 females, with a mean age of （66. 60 ±7. 19）years old and in the first or second grade of Hoehn＆Yahr standard, as well as 2 male and 2 female normal volunteers, with a mean age of （70. 50 ± 0. 58） years old, were studied with RAC-PET. Results [^11C] RAC was evident in caudal and capsule nucleus, but not in cortex, cerebellum, thalamus and brain stem, which was accordant with the distribution of D2 receptor. In early and untreated PD patients, the [ ^11 C ] RAC binding index of the head of caudal nucleus and capsule nucleus on the contralateral side to the diseased limb （ being 2. 94 ± 0. 33, 3.34 ± 0. 27 and 3. 27 ± 0. 37 ） was higher than that of normal subjects （ value being 2. 54 ± 0. 49, 2. 89 ± 0. 48 and 2. 72 ± 0. 19 ）, P being 0. 046,0. 013 and 0. 022, respectively. The [ ^11 C ] RAC binding index of the head of caudal nucleus and capsule nucleus on the ipsilateral side to the diseased limb, being 2. 78 ±0. 31,3. 22 ±0. 38 and 3. 10 ±0. 29, was higher than that of normal subjects, being 2. 63 ± 0. 19, 2. 93 ± 0. 21 and 2. 76 ± 0. 27 respectively, without significant difference. [ ^11 C ] RAC binding index on the side contralateral to the diseased limb was higher than that on the ipsilateral side, which was 2. 78 ±0. 31, 3. 22 ±0. 38 and 3. 10 ±0.29, respectively, in PD patients without significant difference. The index of the two sides had no difference in normal subjects（ value being 2. 54 ± 0. 49, 2. 89 ± 0. 48, 2. 72 ± 0. 19 and 2. 63 ± 0. 19, 2. 93 ± 0.21, 2. 76 ± 0. 27）, while it was higher in capsule nucleus （ being 2. 85 ± 0. 15 and 2.80±0.12） thanthatincaudalnucleus（being2.58±0.07）, P〈0.05. Conclusions [^11C]RAC is a specific tracer of D2 receptor and can be used in vivo to evaluate D2 receptor. D2 receptor is upregnlated in early and untreated PD patients.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2006年第6期374-378,共5页
Chinese Journal of Neurology
