摘要
目的:探讨胃肠道间质瘤(GIST)的临床病理、免疫组织化学特点.方法:对45例发生在胃肠道的间质瘤行常规检查及免疫组织化学染色,进行观察和对比分析.结果:GIST的肿瘤细胞较经典的平滑肌瘤更加丰富,胞质嗜酸性较弱,瘤细胞为梭形或上皮样,或梭形与上皮样细胞混合存在,胞质内常见空泡形成,排列成交织束状、弥漫片状、栅栏状或轮辐状,有较为特征的细胞团巢形成.间质或血管壁玻璃样变性.结论:GIST有较为独特的组织形态学特点,CD117和CD34联合应用有助于鉴别诊断.
AIM： To explore the clinicopathology of gastrointestinal stromal tumor（GIST） and its immunohistochemical features. METHODS： Observation and contrast analysis were made after the routine check and staining in 45 GIST cases. RESULTS： GIST cells were more abundant than the typical leiomyoma cells and presented spindle-shaped or epithelioid, or a coexistence of spindle-shaped or epithelioid ceils; in cytoplasm, the acidophilia decreased, and vacuoles were found arranged like intertexture, widespread lamellar, palisade or wheel radiation; typical cell nesting was formed; stroma or vessel wall showed a hyaline degeneration. CONCLUSION： GIST possesses unique histomorphological characteristics and the combination of CD117 and CD34 was helpful to differential diagnosis.
出处
《第四军医大学学报》
北大核心
2006年第14期1322-1324,共3页
Journal of the Fourth Military Medical University
关键词
胃肠肿瘤
间皮瘤
病理形态学
免疫组织化学
诊断
鉴别
gastrointestinal neoplasms
mesothelioma
pathomorphology
immunohistochemistry
diagnosis,differential
