摘要
目的:探讨环氧合酶-2(COX-2)和血管内皮生长因子(VEGF)在上皮性卵巢癌发生发展中的作用。方法:采用免疫组化S-P法检测13例浆液性囊腺瘤、10例交界性囊腺瘤、70例囊腺癌组织中COX-2及VEGF的表达。结果:①COX-2表达强度在浆液性囊腺瘤和囊腺癌间比较差异具有显著性(P<0.05);COX-2表达强度在上皮性卵巢癌的不同临床分期(早期、晚期)间比较差异具有显著性(P<0.05)。②VEGF表达强度在浆液性囊腺瘤和囊腺癌间比较差异具有显著性(P<0.05);在浆液性囊腺瘤和交界性囊性瘤间比较差异具有显著性(P<0.05);VEGF阳性表达率早期上皮性卵巢癌低于晚期(P<0.05),无淋巴结转移组低于有淋巴结转移组(P<0.05)。③COX-2及VEGF在上皮性卵巢癌中的表达具有协同作用。结论:COX-2与VEGF在上皮性卵巢癌的发生发展中起着不同的作用,二者的联合监测对卵巢癌的诊断、临床分期、预后有指导作用。
Objective To explore the effects of cyclooxygenase （COX-2） and vascular endothelial growth factor （VEGF） on occurrance and progress Of epithelial ovarian carcinoma. Methods The expressions of COX-2 and VEGF in 13 patients with serous cystadenoma, 10 patients with borderline serous cystadenoma and 70 patients with serous cystadenocarcinoma were detected by immunohistochemical method. Results ①The positive rate of COX-2 expression of cystadenocarcinoma was obviously higher than that of cystadenoma （P〈0.05）, and there was obvious difference between early and late stage （P〈0.05）.②The positive rates of VEGF expression of cystadenocarcinoma was obviously higher than that of cystadenoma （P〈0. 05）, and borderline serous cystadenoma was obviously higher than that of cystadenoma （P〈0.05）, and there was obvious difference between early and late stage （P〈0.05）. The positive rate of VEGF expression in cases with lymph node metastasis was significantly higher than that in those without lymph node metastasis （P〈0.05）. ③The expressions of COX-2 and VEGF in epithelial ovarian carcinoma had synergetic effect. Conclusion COX-2 and VEGF have difference effects in occurrance and progression of epithelial ovarian carcinoma, the monitoring of COX-2 and VEGF can guide the diagnosis, clinical staging and prognosis of epithelial ovarian carcinoma.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2006年第4期665-668,共4页
Journal of Jilin University：Medicine Edition
基金
吉林省科技厅资助课题(990569)
关键词
卵巢肿瘤
环氧合酶-2
血管内皮生长因子
免疫组织化学
ovarian neoplasma
cyclooxygenase-2
vascular endothelial growth factor
immunohistochemistry
