摘要
目的:评价川芎嗪(ligustrazine,LT)和透明质酸钠(sodium hyaluronate,SHA)对兔心脏术后心包粘连心肌粘连、组织形态及血液中白细胞(WBC)、纤维蛋白原(FIB)浓度的影响。方法:建立兔心脏术后心包粘连模型。各组分别给予:透明质酸钠组术后心包腔灌注透明质酸钠(5 mg/只);川芎嗪组术后静脉注射川芎嗪(6.7 mg.kg-1),qd,共7 d;模型组及假手术组给予等容积的生理盐水。各组动物于术后20 d处死,观察心包粘连及病理形态;各组动物于术后7 d静脉取血,测定血常规及血浆FIB浓度。结果:模型组心肌紧密粘连,纤维组织增生,各用药组粘连和增生减轻,兔血液WBC及血浆FIB浓度显著增高,与假手术组相比显著增高(P<0.01),SHA组、LT组均可降低WBC及血浆FIB浓度,与模型组比较显著降低(P<0.01);SHA组与LT组比较无统计学意义(P>0.05)。结论:透明质酸钠和川芎嗪对兔心脏术后心包粘连的形成均有保护作用,其作用与降低WBC及血浆FIB水平可能有关。
AIM： To evaluate the protective effect on rabbit＇s postoperative pericardial adhesion of ligustrazine and sodium hyaluronate on adhesions, pathological histology, fibrinogen and white blood cells. METHODS： Rabbits were randomly divided into five groups, 24 rabbits were used to make model with pericardial adhesions to four groups. Sodium hyaluronate group was injected with 5 mg sodium hyaluronate to pericardial cave of each rabbit after the operation; ligustrazine group was injected 6.7 mg· kg^-1 ligustrazine to vein after the operation, qd, 7 d enough; equal quantity of normal saline was injected in model group and sham operation group. The rabbits were sacrificed 20 days later . Adhesions tissues and pathological morphous were observed and analysis were done, FIB and WBC were tested at 7 d time point. RESULTS：Pericardial adhesions and fiber hyperplasia were significant in model group. Compared with sham group, the concentration of FIB and the amount of WBC were obviously increasing （P 〈 0.01 ）. Compared with model group, sodium hyaluronate group and ligustrazine group could significantly reduced the concentration of FIB（ P 〈 0.01）. There was no statistical meaning between sodium hyaluronate group and ligustrazine group （ P 〉 0.05 ）. CONCLUSION： These results demonstrate that sodium hyaluronate and ligustrazine can effectively prevent postoperative perieardial adhesion. The protective effect is, to some degree, related to the inhibition of FIB and WBC.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2006年第6期665-668,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
粘连
透明质酸钠
川芎嗪
纤维蛋白原
白细胞
adhesions
sodium hyaluronate
ligustrazine
fibrinogen
white blood cells
