摘要
目的研究阿奇霉素(大环内酯类抗生素)在中国健康人体的药代动力学。方法 10名健康志愿者单剂量口服阿奇霉素500 mg后,高效液相色谱-紫外检测法测定血清药物浓度;用AIC法结合F检验判别房室模型, DAS程序计算药代动力学参数。结果主要的药代动力学参数:Ka为(0．87 ±0．27)h-1,t1／2β为(39．66±10．85)h,tmax为(2．60±0．52)h,Cmax为(451．19 ±67．72)μg·L-1,CL／F为(0．56±0．13)L·(h·kg)-1,AUC0-144和 AUC0-∞分别为(13．68±2．92)mg·h·L-1和(13．71±2．91)mg·h·L-1。结论最佳房室模型为二室模型。
Objective To study the pharmacokinetics of azithromycin tablet in Chinese healthy volunteers. Methods Ten healthy volunteers were given a single oral dose of 500 mg azithromycin tablet. The serum concentrations of azithromycin were determined by HPLC - UV. The compartment model was fitted by AIC -F test method The pharmacoki- netic parameters were calculated by DAS program. Results The main pharmacokinetic parameters of azithromycin for orally administered tablet were as follows： Ka was （0.87±0.27）h^-1 ,t1/2β was （39.66± 10.85） h,tmax was （2.60 ±0.52） h,Cmax was （451.19 ±67.72）μg·L^-1 ,CL/ F was （0.56±0.13）L · （h · kg）^-1 ,AUC0-144 was （13.68±2.92） mg · h· L^-land AUC0-∞ was （13.71±2.91） mg·h· L^-1. Conclusion The pharmacokinetics was best fitted to a two -compartment model.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2006年第3期195-197,共3页
The Chinese Journal of Clinical Pharmacology
基金
深圳市卫生科技计划资助项目(200006018)
