摘要
目的观察急性脑梗死后不同时期血清铁蛋白(serum ferritin,SF)、丙二醛(MDA)及超氧化物歧化酶(SOD)水平变化;观察抗自由基药物依达拉奉治疗后SF、MDA及SOD的变化及神经功能恢复情况。方法68例脑梗死患者(脑梗死组)随机分为两组,依达拉奉治疗组(30例)和常规治疗组(38例)。测定SF、MDA及SOD并与30例健康对照组进行比较,同时行神经功能缺损评分(CSS),并测定48 h头颅CT和(或)MRI的影像学容积。结果脑梗死组SF水平均较健康对照组增高,差异有显著性;SF水平与MDA呈正相关关系;SF水平与SOD呈负相关关系;SOD水平与MDA呈负相关关系;依达拉奉治疗组SF水平上升趋势较常规治疗组低,CSS值差异显著(P<0.05)。结论SF可能参与了急性脑梗死缺血后自由基损害的重要病理生理过程,其表达增高的程度与病情严重程度呈正相关关系,依达拉奉治疗能有效改善患者的病损程度。
Objective To observe the changes of serum ferritin （SF）, MDA and SOD in the patients with acute cerebral infaretion（ACI） and recovery of these changes after therapy with edaravone. Method Sixtyeight patients with ACI were divided into two treatment groups i. e. ederavone treatment group （30 cases） and conventional treatment group（38 cases）, at random. SF, MDA and SOD were determined in these patients, China Stroke Scale（CSS scale）was used to evaluate the extent of neurological defect and the ischemic volume of ACI was calculated by CT scan or MRI. Results SF level was higher in ACI group than in healthy control group. The increase in level of SF was slower in edaravone therapy group than in conventional therapy group. SF level was positively correlated with the MDA level and negatively correlated with the SOD level. The MDA level was also negatively correlated with the SOD level. Conclusions SF may play a role in the pathophysio- logical events during the acute phase of ACI. Edaravone therapy can raise the level of SOD, reduce the level of MDA and control the level of SF in acute phase of ACI by scavenging free radicals.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2006年第8期546-548,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
脑梗塞
铁蛋白
丙二醛
超氧化物歧化酶
自由基清除剂
cerebral infarction
ferritin
malondialdehyde
superoxide dismutase
free radical scavengers
