摘要
目的 探讨甲氨蝶呤（MTX）不同治疗方案对未破裂型异位妊娠的疗效比较。方法2001年1月至2005年12月，我们对160例未破裂型异位妊娠病例进行治疗观察，随机分成4组：Ⅰ组采用MTX50mg／m^2，每天上午im1次，共3次，下午用四氢叶酸（CF）im，1次，d，共3次；Ⅱ组采用MTX50mg／m^2单次im；Ⅲ、Ⅳ组分别同Ⅰ、Ⅱ组方案的同时均加用米非司酮25mg，2次，d，po，连续3d。结果Ⅰ组成功率为72．50％（29／40）；Ⅱ组成功率92．50％（37／40）；Ⅲ组成功率为72．50％（29／40）；Ⅳ组成功率为90．00％（36／40）；Ⅰ、Ⅱ组间及Ⅲ、Ⅳ组间均有显著性差异（P〈0．01）；Ⅰ、Ⅲ组间及Ⅱ、Ⅳ组间差异无显著性（P〉0．05）。结论 使用MTX50mg／m^2单次im，较分次im加CF解救方案疗效好，而加用米非司酮方案并未增加疗效，反而相应地增加了药物的不良反应。
Aim To explore the efficacy of different regimens of Methotrexate in treating ectopic pregnancy. Methods 160 cases of un-rupture ectopic pregnancy were enrolled into this study from Jan 2001 to Dec 2005. All patients were randomized into 4 groups： group I received MTX 50mg/m^2, im once, every morning for 3 days, CF im once, every aftetnoon for 3days; group II received only once 50mg/m^2 im. only once; group II and IV received same regimens as group I and II except additional mifepristone 25mg, bid. po. Results Achievement ratio were 72.50% （ 29/40 ）, 92.50% （ 37/40 ） ,72.50% （ 29/40 ） and 90.00% （ 36/40 ） in 4 groups, respectively. There was significantly difference between group Ⅰ and Ⅱ, （P〈0.05）, and between group Ⅲ and Ⅳ （P〈0.05）. No significantly difference was found between group I and III, and between group II and IV. Conclusion Efficacy of MTX 50mg/m^2 im. only once was better than that of MTX 50mg/m^2, im once, every morning for 3 days. Mifepristone failed to show synergic effect to the MTX regimen, but only aggravate the side effect.
出处
《世界感染杂志》
2006年第4期341-342,347,共3页
World Journal of Infection
关键词
异位妊娠
甲氨蝶呤
米非司酮
疗效
ectopic pregnancy
Methotrexate
mifepristone
efficacy
