摘要
AIM： To investigate the effect of shenfu injection on gastrointestinal microcirculation after myocardial ischemic-reperfusion （IR） injury in rabbits and probe into the mechanism. METHODS： Forty healthy flap-eared white rabbits were randomly divided into 4 groups： IR injury control group （group Ⅰ ）, shenfu injection 5 mL/kg per h group （group Ⅱ）, shenfu injection 10 mL/kg per h group （group Ⅲ） and shenfu injection 20 mL/kg per h group （group Ⅳ）. The four groups were treated with Lactated Ringer＇s solution, shenfu injection 5, 10, and 20 mL/ kg per h were infused intravenously 30 min before experiment respectively. The values of hemodynamics [mean arterial pressure （MAP）, heart rate （HR）, gastric intramucosal partial pressure of carbon dioxide （PCO2）, blood gas analysis and pH] were measured and compared with those before myocardial ischemia, 60 min after myocardial ischemia and 60, 90, and 180 rain after reperfusion. RESULTS： The MAP, HR and gastric intramucosal pH were （70.50 ± 4.50） kPa, （165 ± 14） beats per rain, 7.032 ± 0.024 in group Ⅰ 60 min after myocardial ischemia, which were significantly decreased compared with those before myocardial ischemia （88.50 ± 9.75 kPa, 217 ± 18 beats per rain, 7.112 ± 0.035, P 〈 0.05）. The MAP, HR and gastric intramucosal pH were significantly decreased in group Ⅰ 60, 90, and 180 min after reperfusion （61.50 ± 5.25 kPa, 133 ± 31 beats per rain, 6.997 ± 0.025） compared with those before reperfusion respectively （P 〈 0.05）, whereas the values were insignificantly different in groups Ⅱ, Ⅲ or Ⅳ after reperfusion, compared with those before reperfusion, and there were no significant differences between groups Ⅱ, Ⅲ, and Ⅳ after reperfusion. CONCLUSION： Pre-infusion of shenfu injection has a protective effect on gastrointestinal microcirculation after myocardial IR injury in rabbits, in a dose independent manner.
瞄准：在心肌的 ischemic-reperfusion (红外) 以后在胃肠的微循环上调查 shenfu 注射的效果在进机制的兔子和探针的损害。方法：四十只健康大耳朵的白兔子随机被划分成 4 个组：红外损害控制组(组我) ， shenfu 注射 5 mL/kg 每 h 组织(组 II ) ，每 h 组(组 III ) 和 shenfu 注射， 20 mL/kg 每 h 组织的 shenfu 注射 10 mL/kg (组 IV ) 。四个组与喂奶的 Ringer 的答案被对待， shenfu 注射 5， 10，和 20 mL/ kg 静脉内地每 h 被灌输在实验前的 30 min 分别地。血液动力学的价值[吝啬的动脉压(地图)，心搏率( HR )，二氧化碳( PCO2 )的胃的 intramucosal 分压，血气体分析和 pH ]被测量并且与那些相比以前心肌的局部缺血，在心肌的局部缺血以后的 60 min 并且 60 ， 90 ，并且在灌注以后的 180 min 。结果：地图， HR 和胃的 intramucosal pH 是( 70.50 +/- 4.50 ) kPa ，( 165 +/- 14 )每 min 跳动， 7.032 +/- 0.024 在组我在心肌的局部缺血以后的 60 min ，它是显著地在心肌的局部缺血前与那些相比减少了( 88.50 +/- 9.75 kPa ， 18 每 min 打败的 217 +/-， 7.112 +/- 0.035 ， P < 0.05 )。地图， HR 和胃的 intramucosal pH 显著地在组被减少我在灌注以后的 60 ， 90 ，和 180 min ( 61.50 +/- 5.25 kPa ， 31 每 min 打败的 133 +/-， 6.997 +/- 0.025 )与那些相比在灌注前分别地( P < 0.05 )，而价值是在在灌注以后的组 II ， III 或 IV 不同的不足道，与那些相比在灌注前，并且在在灌注以后的组 II ， III ，和 IV 之间没有有效差量。结论：shenfu 注射的注入前在兔子在心肌的红外损害以后在胃肠的微循环上有保护的效果，以一种剂量独立人士方式。
