摘要
用正交试验筛选鬼臼毒素冻干脂质体的优化工艺,并以HPLC法测定其包封率。得到优化工艺为磷脂-甘露醇保护剂为1：8(摩尔比),pH7．2磷酸盐缓冲液为水合介质,平均包封率为78．5%。
The orthogonal experimental design was used to optimize the preparation of podophyllotoxin freeze-dried liposomes. A HPLC method was used to determine the entrapment rate of the product. The results showed the optimal condition was phospholipids-mannitol （1 ： 8）, mannitol as the protector, pH 7.2 PBS as medium. The average entrapment rate was 78.5 %.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2006年第8期547-549,共3页
Chinese Journal of Pharmaceuticals
