摘要
目的:探讨蛭萸颗粒治疗糖尿病周围神经病变的作用机理。方法:以链脲佐菌素制造大鼠糖尿病周围神经炎模型,以蒸发光散射技术检测蛭萸颗粒作用下大鼠坐骨神经肌醇含量;测定大鼠坐骨神经中Na+-K+-ATP酶活性;测定大鼠红细胞中SOD活性和MDA含量;在电镜下观察大鼠坐骨神经、胰腺、肾脏组织的超微结构变化。结果:蛭萸颗粒可增加糖尿病周围神经病变大鼠坐骨神经中肌醇含量,提高Na+-K+-ATP酶活性,改善坐骨神经、胰腺细胞的超微结构,对肾小体结构无明显改善作用,对模型大鼠红细胞中SOD活性及MDA含量也无作用。结论:蛭萸颗粒对糖尿病周围神经炎症状的改善有意义。
AIM ： To discuss the mechanism of action of Zhiyu Granules on treating diabetic peripheral neuritis. METHODS ： The model of diabetic peripheral neuritis in mice was induced by streptozotocin. The effect of Zhiyu Granules on the contents of sciatic nerve inositol in model mice through ELSD （evaporative light scattering detectot） was examined, and the activity of Na^＋ -K ^＋ pump in sciatic nerve was measured, and the activity of SOD and the contents of MDA in erythrocytes were detected, and the ultrastructures of sciatic nerve, pancreas and kidney in model mice were observed by electric microscope. RESULTS： Zhiyu Granules could increase the contents of sciatic nerve inositol in model rats, and enhance the activity of Na^＋-K^＋ pump, and improve the uhrastructures of sciatic nerve and pancreas cell. Zhiyu Granules couldn＇ t improve the ultrastructure of renal corpuscles, or affect the activity of SOD and the contents of MDA in erythrocytes of model mice yet. CONCLUSION： Zhiyu Granules is effective in clinical treatment of diabetic peripheral neuritis.
出处
《中成药》
CAS
CSCD
北大核心
2006年第8期1175-1177,共3页
Chinese Traditional Patent Medicine
