摘要
自身免疫性肝病系机体自身免疫反应过度造成肝组织损伤的疾病,主要包括自身免疫性肝炎(AIH)、发性胆汁性肝硬化(PBC)、原发性硬化性胆管炎(PSC)和变异综合征等。其病因可能与遗传易感性和分子模拟机制有关。本文重点介绍病因、发病机制、临床表现、诊断和治疗。血清自身抗体ANA,SMA,AMA,LKM,pANCA,抗SLA,AMAM2检测有助于明确诊断。AIH可采用免疫抑制剂和皮质激素治疗,PBC和PSC可选用熊去氧胆酸和皮质激素,终末期可考虑采用肝移植治疗。
Autoimmune liver disease is the disease that liver tissue is danmified by autoimmune reaction overly, including AIH, PBC, PSC and aberrance syndrome. The pathogeny is maybe related with inheritance susceptibility and molecule simulation pathogenesis. This article emphatically introduces pathogeny, pathogenesis, clinic manifestation, diagnosis and treatment. Checking ANA, SMA, AMA, LKM, pANCA, anti-SLA, AMA-M2 are helpful to diagnose definitely. AIH can be treated by immunosuppressant and cortical hormone. PBC and PSC can be treated by bear deoxy gallbladder acid and cortical hormone. In the last period, liver transplant can be chosen .
出处
《实用医院临床杂志》
2006年第5期25-27,共3页
Practical Journal of Clinical Medicine
关键词
自身免疫性肝病
病因
诊断
治疗
Autoimmune liver disease
Pathogeny
Diagnosis
Treatment
