摘要
目的探讨益肾汤联合西药治疗糖尿病肾病的临床疗效。方法选择2004年6月～2006年1月在商丘医专附属医院就诊的糖尿病肾病Ⅳ期患者90例，分为两组：对照组按常规给予格列喹酮30mg／d，分早、晚2次饭前30min口服；胰激肽原酶240u／次，3次／d口服；依那普利10mg／d，分1～2次口服。治疗组在对照组用药基础上加用自拟益肾汤治疗，两组均以8周为1疗程。观察两组患者的临床疗效及治疗前、后空腹血糖、血压、24h尿蛋白定量、尿白蛋白排泄率、肾功能、血脂的变化。结果两组患者临床疗效间差别有显著性意义（P〈0．01）。治疗前两组患者的空腹血糖、血压、24h尿蛋白定量、尿白蛋白排泄率、肾功能、血脂间差别均无显著性意义（P〉0．05）．治疗后上述各指标间差别均有显著性意义（P〈0.01）。结论益肾汤联合西药治疗糖尿病肾病Ⅳ期的疗效优于单纯西药治疗，可有效降低各项监测指标。
Objective To evaluate the clinical curative effects of Yishentang combined with western medicine on diabetic nephropathy. Methods 90 patients with diabetic nephropathy were chosen in the First Hospital Affiliated to Shangqiu Medical College from June 2004 to January 2006. Patients were randomly divided into two groups. 45 patients in the control group were treated routinely with gliquidone （taken orally 30 mg/d at half an hour before breakfast and lunch twice per day） , pancreatic kininogenase （taken orally 240U once and three times per day） and enalapril （taken orally 10 mg once or twice per day）. 45 patients in the treatment group received Yishentang on the basis of the medicines used in the control group. Eight weeks were considered as one treatment course in both groups. The clinical curative effects and the change of related indexes were observed before and after therapy in two groups. Results There were significant differences in the curative effects between two groups （ P 〈 0.01 ） ; there were no significant differences in the markers such as fasting blood - glucose, blood pressure, 24 h urinary protein, urinary albumin excretion, nephric function, blood - fat in the two groups before the treatment （ P 〉 0. 05 ） , but there were significant differences after the treatment （ P 〈 0.01 ）. Conclusion Yishentang combined with western medicine has better curative effects on Ⅳ diabetic nephropathy .
出处
《中国全科医学》
CAS
CSCD
2006年第18期1554-1556,共3页
Chinese General Practice
关键词
糖尿病肾病
益肾汤
治疗结果
Diabetic nephropathies
Yishentang
Treatment outcome
