摘要
目的:探讨参麦注射液对急性心肌梗死(AMI)大鼠心室重构的影响。方法:通过结扎冠状动脉前降支建立AMI模型大鼠,AMI后24h存活的48只大鼠随机分为四组:AMI后1周模型组;AMI后参麦注射液治疗1周组;AMI后2周模型组;AMI后参麦注射液治疗2周组。另设1周、2周假手术组各8只。治疗组每日腹腔注射参麦注射液1次,AMI模型组和假手术组大鼠腹腔注射等量的生理盐水。测量各组心室重构参数。结果:与假手术组比较,AMI后1周时,心室腔已明显扩大(P<0.05);到梗死后2周时,心室腔内径扩大更明显,与假手术组相比有显著性差异(P<0.01),且心室重量指数(VWI)比假手术组明显增加(P<0.05)。参麦注射液治疗2周后可改善心梗后心室重量指数增加、心室腔扩大的病理变化(P<0.05)。结论:参麦注射液能改善大鼠AMI后心室重构。
Objective： To investigate the effects of Shenmai injection on ventricular remodeling after acute myocardial infarction（AMI） in rats. Methods： AMI was established by ligating the anterior descending coronary artery in male SD rats. Twenty-four hours after the procedure, the 48 surviving rats were seperated randomly into AMI one- week group, AMI two-week group,Shenmai injection treatment one-week and two- week groups （n= 12）. One-week sham-operated and two-week sham-operated groups were taken randomly as non-infarction control. After treated with the drug and placebo by intraperitoneal injection（IP）, the ventricular remodeling of one-week and two-week groups was assessed. Results： Compared with sham-operated group, left ventricular diameter（LVD） was increased significantly in AMI group after a week（P〈0.05）;LVD and ventricular weight index（VWI） were all increased significantly（P〈0.05 or 0.01）in AMI group after two weeks. In comparison with AMI group, LVD and VWI were all decreased significantly in Shenmai injection treatment group after two weeks（P〈0.05）. Conclusion： Shenmai injection can prevent left ventricular remodeling after AMI in rats.
出处
《河北北方学院学报（医学版）》
2006年第4期9-12,共4页
Journal of Hebei North University:Medical Edition
基金
河北省中医药管理局资助项目(编号:05019)
关键词
参麦注射液
急性心肌梗死
心室重构
Shenmai injection
Acute myocardial infarction
Ventricular remodeling
