摘要
目的探讨冠心病患者载脂蛋白E（ApoE）基因型与超敏C-反应蛋白（HsCRP）及胆固醇／高密度脂蛋白胆固醇（TC／HDL—C）比值的相关性。方法采用Multi ARMS快速分型法检测105例冠心病患者和110例正常健康体检者ApoE基因型，同时测定其总胆固醇（TC）、甘油三酯（TG），低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL—C）、HsCRP载脂蛋白AI（ApoAI）、载脂蛋白B（ApoB）的浓度，并计算TC／HDL-C比值。结果冠心病组E4等位基因频率、HsCRP和TC／HDL—C均高于对照组。结论三者联合检测，可进一步预测将来发生冠状脉综合征的危险性。
Objective To explone the interralation between polymorphism of apolipoprotein E and HsCRP in patients with coronary heart disease.Methods Polymorphism of ApoE gene were rapidly detected by Multi ARMS. Results Compared with control group, the distribution of ApoE3 allele＇s frequencies was significantly decreased （P〈 0.01）,but ApoE4 allele＇s frequencies incresased （P〈 0.01） in coronary heart disease group.There was marked difference in plasma HsCRP and TC/HDL-C among the patients with different ApoE alleles.Conclusion Combined detection may further predict the risk of coronary artery syndrome.
出处
《中华临床医学卫生杂志》
2006年第7期24-26,共3页
China Journal of Clinical Medicine Hygiene
