摘要
目的：探讨老年恶性淋巴瘤（ML）的临床特点、治疗及国际预后指数（IPI）的应用价值。方法：回顾性分析1998～2003年间59例首程治疗的老年ML患者的临床资料。本组患者37例接受治疗，大部分单纯采用联合化疗的方法，部分采用局部放疗加化疗或手术后加化疗的方法。结果：59例ML患者1、3、5年生存率分别为77．9％（46／59），41．1％（23／56），9．4％（5／53），而治疗组1、3、5年生存率分别为81．1％（30／37），45．9％（17／37），13．5％（5／37），其中存活5年以上者均为达完全缓解（CR）者。非霍奇金淋巴瘤（NHL）根据IPI分组，低危组、低中危组、中高危组、高危组中位生存期（MST）分别为88个月、60个月、52个月、6个月，其生存时间差异有统计学意义（P＜0．01），各组之间的CR率也存在统计学意义（P＜0．01）。Cox多因素分析显示，影响预后的独立因素为病理类型和IPI。结论：IPI是判断老年ML预后的重要指标，老年ML仍应考虑积极的综合治疗。
Objective：To investigate the clinical characteristics, international prognostic index and treatment of elderly patients with malignant lymphoma. Method： From 1998 to 2003, 59 elderly previously untreated patients with malignant lymphoma were retrospectively reviewed. 37 patients received treatment, which includes combined chemotherapy to majority and chemotherapy combined with radiotherapy or surgery to minority. Result：The overall survival rate at 1, 3 and 5 years for all patients were 77.9% ,41. 1%, 9.4% respectively. And the overall survival rate at 1, 3 and 5 years for patients who had received treatment were 81.1%, 45.9%, 13.5% respectively. As for international prognostic index（IPI）, median survival time （MST） was 88 months for low risk, 60 months for low intermediate risk, 52 months for high intermediate risk, 6 months for high risk, respectively. There was sig nificant difference among them （P〈0.01）. IPI was also a strong predictor of complete response （ P〈0.01）. Multivariate analysis by Cox regression showed that pathological type and IPI were independent prognostic fac tors. Conclusion： International prognostic index is an important prognostic factor for elderly patients with Non Hodgkin＇s lymphoma and the combined modality therapy may be optimal for elderly patients with malignant lyre phoma.
出处
《临床血液学杂志》
CAS
2006年第5期276-278,共3页
Journal of Clinical Hematology
关键词
老年
恶性淋巴瘤
国际预后指数
Elderly
Malignant Lymphoma
International prognostic index
