摘要
目的探讨可溶性细胞间黏附分子-1(sICAM-1)水平与白癜风活动程度的关系和意义。方法sICAM-1检测采用酶联免疫吸附试验(EL ISA)方法。结果(1)白癜风患者血清sICAM-1平均水平为769.80 ng/m l,显著高于正常对照组642.40 ng/m l(P<0.001)。(2)进展期白癜风患者血清sICAM-1平均水平为802.32 ng/m l,显著高于稳定期654.15 ng/m l(P<0.001)。(3)泛发型白癜风患者血清S ICM-1平均水平为801.40 ng/m l,显著高于局限型675.45 ng/m l(P<0.001)。(4)稳定期和局限型白癜风患者血清sICAM-1水平与正常对照组差异无显著性(P均>0.05)。结论sICAM-1可能参与白癜风的发病,与白癜风活动性和严重程度相关。
Objective To investigate the relationship between degree of sICAM-1 and degree of vitiligo activity,and discuss its significance. Methods sICAM-1 was detected by enzymelinked immunoabsorbent assay. Results ①The average concentration of sICAM-1 in the sera of patients with vitiligo is 769.80 ng/ml,which is significantly higher than the level of healthy group as control（642.40 ng/ml,P〈0.001）.②The average concentration of sICAM-1 in the sera of patients with progressive vitiligo is 802.32 ng/ml ,which is significantly higher than the level of stahle vitiligo （654.15 ng/ml,P〈0.001）.③The average concentration of sICAM-1 in the sera of patients with diffuse vitiligo is （801.40 ng/ml ,P〈0.001）. ④There is no significant difference（P〉0.05）between the degree of sICAM-1 in the sera of patients with stable and localized vitiligo and the degree of healthy control. Conclusion It is possible that sICAM-1 is correlated with cause of vitiligo,and the degree of vitiligo activity and seriousness.
出处
《淮海医药》
CAS
2006年第6期449-450,共2页
Journal of Huaihai Medicine
