摘要
阿霉素(DR)及其前体脂质体(DRPL)iv或ip对小鼠侈植肉瘤180(S_(180))、肝癌实体型(Heps)的肿瘤生长具有明显的抑制作用,两者抑瘤作用相近,DR有明显降低小鼠体重和外周血中白细胞的作用。与对照纽相比,DRPL及DR ip给药皆显著延长S_(180)、Heps、EAC腹水型小鼠移植瘤的存活天数的作用,但与相同剂量的DR相比,DRPL高、中剂量组有明显延长小鼠移植瘤的存活天数作用,其治愈率DRPL对S_(180)、Heps、EAC腹水型小鼠移植瘤分别为70%,50%和60%,而DR则为20%,10%和10%。
The effects of doxorubicin proliposome (DRPL) on the experimental tumour: S_(180), Heps and EC in mice were described. The results showed that the growth of S_(180) and Heps in mice was significantly (P<0. 01) inhibited by DRPL following ip and iv administration. The effects of DRPL on S_(180) and Heps was similar to those of doxorubicin(DR),but the weight and peripheral leucocyte count of mice were significantly decreased(P<0.01) by DR. Following ip administration both DR and DRPL could significantly prolong(P<0.01) the survival time of mice with S_(180), Heps of ascitic type and EAC compared with control groups, but the effect of DRPL was more significant than that of DR(P<0.05). The survival rate of mice with S_(180) of ascitic type, Heps of ascitic type and EAC were 70%, 50%, 60% respectively in DRPL group and were 20%, 10%, 10% respectively in DR group.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1996年第10期609-612,共4页
Journal of China Pharmaceutical University
基金
江苏省应用基础项目
关键词
阿霉素
脂质体
抗肿瘤作用
Doxorubicin proliposome
Doxorubicin
Antitumour
