摘要
目的:研究直结肠癌细胞线粒体的超微结构。方法:收集香港大学玛丽医院直结肠外科手术切除的直结肠癌大体病检标本共18例。用透射电镜观察线粒体,并取正常黏膜作对照组。结果:直结肠癌细胞线粒体肿胀,空泡化,脊稀少,排列紊乱。凋亡细胞的线粒体比非凋亡细胞的线粒体多,形态更接近正常。结论:线粒体超微结构的异常与肿瘤的代谢方式及细胞凋亡有密切关系。
Objective：To study the ultrastructure of mitochondria of colorectal cancer. Methods：18 cases of colorectal cancer specimens were collected from Mary hosipital in University of Hong Kong . The ultrastructures of the specimens from colorectal cancer lesions and normal mucosa were observed with electron microscopy. Results： The resuits showed that the colorectal cancer cells had swollen and vacuolated mitochondria with disarrangement and unfolding of cristae. In addition,apoptotic colorectal cancer cells had fewer mitochondria than non-apoptotic cancer cells in number,and it＇s structure was more normal. Conclusion：The ultrastructure abnormalities of mitochondria is related to the metabolism and apoptosis of tumor.
出处
《中国误诊学杂志》
CAS
2006年第17期3277-3279,共3页
Chinese Journal of Misdiagnostics
