摘要
目的观察中药肝能滴丸治疗慢性乙型肝炎患者临床抗病毒疗效。方法选取乙肝病毒主要复制指标HBV-DNA、HBsAg、HBeAg阳性慢性乙型肝炎患者共84例,开放随机分为肝能滴丸治疗组56例和拉米夫定对照组28例,疗程0·5年;观察两组患者血清HBeAg、HBV-DNA的阴转率和肝功能、症状、体征变化情况。结果治疗组HBV-DNA阴转率为54·0%(27/50例)、HBeAg阴转率30·0%(15/50例)、ALT复常率80·0%(40/50例);对照组依次为67·9%(19/28例)、21·4%(6/28例)、75·0%(21/28例);两组比较差异均无显著性(均P>0·05)。治疗组AST复常率98·0%(48/49例),对照组为48·0%(12/25例),两组比较差异有显著性(P<0·01)。治疗组症状改善以胁肋胀痛、纳食减少、倦怠乏力、脘闷腹胀、尿黄最为显著,明显优于治疗前(P<0·05或P<0·01)。结论肝能滴丸对慢性乙型肝炎有较好的近期疗效;能有效抑制HBV复制,改善肝功能及症状体征。
Objective To observe the antiviral efficacy of Ganneng Dripping Pill （GDP） in treating patients with chronic hepatitis B. Methods Eighty-four patients of chronic hepatitis B with positive HBV-DNA, HBsAg, and HBeAg were randomly assigned to 2 groups, the treated group （56 patients） treated with GDP and the control group （28 patients） treated with lamivudine. The therapeutic course for both groups was 6 months. The negative conversion rate of HBeAg and HBV-DNA, changes of liver function, symptoms and physical signs in patients were observed before and after treatment. Results In the treated group, the negative conversion rate of HBV-DNA and HBeAg was 54.0% （27/50） and 30.0% （15/50） respectively, and the ALT normalizing rate was 80.0% （40/50）, while those were 67.86% （19/28）, 21.8% （6/28） and 75.0% （21/28） respectively in the control group, showing no significant difference between the two groups （all P 〉0.05）. However, the AST normalizing rate was 97.96% （48/49） in the treated group, higher than that in the control group （48.0 %, 12/25, P 〈 0.01） ; and the clinical symptoms, especially the poor appetite, lassitude, gastric distention and yellow urine, were improved more significantly in the treated group than those in the control group （P 〈 0.05 or P 〈 0.01）. Conclusion GDP has a favorable short-term effect on chronic hepatitis B, it could effectively inhibit HBV replication and improve the liver function, symptoms and signs in patients.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2006年第9期788-790,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
北京市重大创新基金资助项目(No.D0204003040931)
关键词
慢性乙型肝炎
肝能滴丸
拉米夫定
抗病毒
chronic hepatitis B
Ganneng Dripping Pill
lamivudine
anti-viral therapy
