摘要
目的探讨急性脑梗死患者血清中一氧化氮(nitrogen monoxide,NO)的含量及对神经损伤的作用。方法分为急性脑梗死1组(24小时以内)20例,急性脑梗死2组(24小时-72小时)20例,急性脑梗死3组(72小时-1周)20例,健康对照组20例。采用重氮化反应(Griess法),测定患者血清中NO的含量。结果急性脑梗死1组2组NO含量明显高于对照组,P<0.05,且2组高于1组,3组NO含量与对照组比较无明显差异,P>0.05。结论在急性缺血早期NO的过量生成参与脑梗死患者的神经损伤。
Objective Reseach with the measurement of nitrogen monoxide in the serumand its effects on neural injury of acute cerebral infarction patients.Methods Divided 4 groups,acute cerebral infaction group 1 （ 〈 24 h） 20 cases,acute cerebral infaction group 2（24 h- 72 h） 20 cases,acute cerebral infacfion group 3（72 h- 1 weeks） 20 cases,heathy control group 20 cases. With Griess methed, measure the content of NO during patients serum. Results the content of NO in group 1 and 2group is apparently higher than control group, P 〈 0.05,and group 2 is higherthan group 1 ,the content of NO in group 3 has no difference with controls, P 〉 0.05. Conclusion during the beginning of acute ischemic, excess creation of NO is associated with neural injury of acute cerebral infarction patients.
出处
《中国实验诊断学》
2006年第9期957-958,共2页
Chinese Journal of Laboratory Diagnosis
关键词
一氧化氮
急性脑梗死
神经损伤
nitrogen monoxide （NO）
acute cerebral infarction
neural injury
