摘要
首次报道了中国人庚型肝炎病毒（ＨＧＶ）全基因ｃＤＮＡ的克隆及序列测定。中国庚型肝炎病毒（ＨＧＶＣ９６４）基因全长为９１２８个核苷酸，编码一个长度为２８７０个氨基酸残基的多聚前体蛋白。５端有一个３６７ｂｐ的非翻译区，３端长度为１４７个核苷酸。基因组中Ｇ＋Ｃ占５９．９３％。该株病毒（ＨＧＶＣ９６４）与国外报道的３株ＨＧＶ序列比较，核苷酸同源性为８４．０％～８９．９％，氨基酸同源性均大于９１％。
The full hepatitis G virus (HGV) genome from Chinese was cloned and sequenced from the serum of a blood donor in Hebei Province of China. The sequence of 9 128 bp indicated that it contains a continuous open reading frame (ORF) that could encode a viral polyprotein of 2 870 amino acids. The 5 and 3 untranslated regions are 367 bp and 147 bp, respectively. Compared with published HGV sequences, Chinese HGV shows 84-89% identity at the nucleotide, and 91-94% at the amino acid levels.
出处
《军事医学科学院院刊》
CSCD
北大核心
1996年第4期249-254,共6页
Bulletin of the Academy of Military Medical Sciences
