摘要
目的探讨重度烧伤患者合并急性肾功能衰竭(ARF)的危险因素,为临床防治ARF提供依据。方法观察2002-01～2005-12在我院住院的重度烧伤患者108例,记录合并ARF患者数目,测定其血液生化指标,分析与ARF的相关因素。结果烧伤患者中有46例(42．59%)合并ARF,合并ARF的烧伤患者血液中血管紧张肽Ⅱ(AngⅡ)、去甲肾上腺素(NE)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平均明显高于非ARF组(P＜0．05或P＜0．001)。结论交感神经活性及微炎症状态在重度烧伤合并ARF中可能具有极其重要的作用,尽早控制交感神经活性及微炎症状态对预防重度烧伤合并ARF应该具有重要意义,交感神经亢进及微炎症状态活跃可作为早期诊断烧伤合并ARF的参考指标之一。
Objective To investigate the risk factor of acute renal failure in severely thermal burn in order to provide the method for the prevention of acute renal failure（ ARF）. Methods Clinical data of 108 patients with severely thermal bum （ the second and third degree bum, 30 % or more of total body surface area） were analyzed retrospectively. The related factors of ARF in 46 patients complicated with ARF were also analyzed retrospectively. Results 42.59% patients with severely thermal burn complicated with ARF. Serum angiotensin Ⅱ , norepinephrine, interleukin - 6, interleukin - 8 and tumor necrosis factor -α levels in ARF group were all higher than those in ordinary group significantly （ P 〈 0.001 ）. Conclusion Sympathetic nerve activity and microinflammation maybe play an important.role in severely thermal burn complicated with ARF. To control sympathetic nerve activity and microinflammation as early as possible may be a good method to prevent ARF complicated with severely thermal burn. Sympathetic nerve activity and microinflammation can act as a useful parameter to diagnose ARF with severely thermal burn.
出处
《中国急救医学》
CAS
CSCD
北大核心
2006年第10期666-668,共3页
Chinese Journal of Critical Care Medicine
关键词
烧伤
急性肾衰竭
交感神经
白细胞介素-6
白细胞介素-8
肿瘤坏死因子-Α
Thermal bum
Acute renal failure（ARF）
Sympathetic nerve
Interleukin-6（IL-6）
Interleukin -8（IL-8）
Tumor necrosis factor-α（TNF-α）
