摘要
目的观察由奥美拉唑联合阿莫西林、克拉霉素等组成的10日序贯疗法根除幽门螺杆菌(Hp)的疗效。方法将经胃镜检查确诊为有明显异常的慢性胃炎和胃十二指肠溃疡且Hp阳性的患者85例随机分组,治疗组(43例)方案为前5d奥美拉唑+克拉霉素,后5d奥美拉唑+阿莫西林+呋喃唑酮;对照组(42例)三联疗法为奥美拉唑+阿莫西林+克拉霉素,疗程7d。结果治疗组Hp根除率为90.7%,对照组Hp根除率为71.4%,两组比较差异有统计学意义(P<0.05)。结论以奥美拉唑、阿莫西林等组成的10日序贯疗法治疗成人Hp感染具有疗效高、耐受性和依从性好等优点。
Objective To evaluate the eradication rate of ten days sequential therapy consisted of omeporazole, clarithromycin, amoxicillin and furazolidone on Helicobacter pylori （Hp） infection. Methods Eighty- five patients with Hp positive pepticulcer and chronic gastritis were randomly divided into two groups. Forty- three patients were treated with omeperazole, clarithromycin at first five days , omeporazole, amoxicillin and furazolidone at the second five days. The control group（42 patients） were trea- ted with omeperazole,clarithromycin and amoxicillin for seven days. Results The eradication rate of ten days sequential therapy was 90.7% and that of control group was 71.4%. The differences between two groups were significant（P 〈 0.05）. Conclusions Ten days sequential therapy is more effective, well tolerated and with higher rate of eradication.
出处
《中国医师进修杂志（内科版）》
2006年第10期24-25,共2页
Chinese Journal of Postgraduates of Medicine
关键词
序贯疗法
幽门螺杆菌
消化性溃疡
慢性胃炎
Sequential therapy
Helicobacter pylori
Pepticulcer
Chronic gastritis
