摘要
近年发现的乳腺癌耐药蛋白属于ATP结合框转运体家族中的G亚家族,是主要的介导肿瘤细胞多药耐药机制的跨膜转运蛋白之一,在临床抗肿瘤治疗中具有重要的意义。本文综述了乳腺癌耐药蛋白的结构特点、表达特征,及其介导的肿瘤细胞多重耐药机制与逆转等方面的研究进展,并展望了今后的研究方向。
Breast cancer resistance protein（BCRP） was discovered in recent years, which is a member of G subfamily in ATP-binding cassette transporter family. As a main trans-membrance transport protein, it mediates multidrug resistance （MDR） in tumor cells and plays an important role in clinic antitumor therapy. It was reviewed in this paper that the BCRP have the characteristics of structure and expression and its mechanism of MDR in tumor cells as well as the con- version of MDR. The development of the field in future was also included in the review.
出处
《生物技术通讯》
CAS
2006年第4期634-636,共3页
Letters in Biotechnology
基金
江苏省卫生厅资助项目(H200541)
关键词
乳腺癌耐药蛋白
多药耐药
半转运体
breast cancer resistance protein
multidrug resistance
half-transporter
