摘要
目的探讨凝血分子标志物和常规凝血指标的检测在脑梗死患者中的临床意义,为脑梗死的诊断和治疗监测提供依据。方法测定90例脑梗死患者血浆中凝血酶原片段1+2(F1+2)、凝血酶-抗凝血酶复合物(TAT)、二聚体(D-D)、抗凝血酶(AT)、蛋白C(PC)、血管性血友病因子(vWF)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT),并与健康正常对照组进行比较。结果脑梗死患者F1+2、TAT、D-D、vWF和健康对照组相比均有显著增高,而PT、APTT、TT、PC和AT与健康对照组相比差异无统计学意义。结论脑梗死患者体内呈高凝状态,凝血酶原活性增强,凝血酶生成增多,纤溶活性增强,抗凝系统活化不足,同时内皮细胞损伤在脑梗死患者的凝血系统激活和发病过程中可能起主要作用,F1+2、TAT、D-D、vWF等凝血分子标志物可以作为脑梗死的诊断指标,而常规的凝血指标不能反映脑梗死患者的高凝状态。
Objective To study the clinical significance of molecular markers and routine coagulation tests in patients with cerebral infarction and to set up a serial programs of laboratory diagnosis, monitoring and treatment of cerebral infarction. Methods Prothrombin fragment l＋2（F1 ＋2） ,throm bin antithrombin Ⅲ complex （ TAT ）, D-dimer （D-D）, Von willebrand Factor （ vWF ）, antithrombin （AT）, protein C （ PC）, prothrombin time （ PT）, activated partial thromboplastin time （APTT） and thrombin time （TT） were determined in 90 patients with cerebral infarction and 60 normal control subjects. Results The levels of F1＋2,TAT,D-D,vWF were significantly higher in patients with cerebral infarction than that in control subjects. But the levels of PC, AT, PT, APTT, TT in patients with cerebral infarction were no different from that in control subjects. Conclusion There were hypercoagulable states in patients with cerebral infarction. The activity of prothrombin is higher, thrombin is generated more, the activity of fibrinolysis is higher too, but anticoagulation system is not sufficiently activated . Meanwhile, perhaps endothelial lesion would be the main role of coagulation system activating and pathogenesis. Molecular markers such as F1＋ 2,TAT, D-D, VWF can be as diagnositic signs but routine coagulable tests can not display the hypercoagulable states in patients with cerebral infarction.
出处
《国际检验医学杂志》
CAS
2006年第10期868-869,共2页
International Journal of Laboratory Medicine
关键词
脑梗死
凝血酶
凝血酶原
生物学标记
抗凝血酶类
Brain infarction
Thrombin
Prothrombin
Biological markers
Antithrom-bins
