摘要
目的:探讨Maspin在非小细胞肺癌(non-small-cell-lung cancer,NSCLC)组织中的表达及临床意义。方法:应用免疫组织化学Picture通用型二步法检测94例NSCLC组织、54例正常支气管黏膜组织、28例肺良性病变中Maspin的表达情况。结果:Maspin在正常支气管黏膜组织及肺良性病变中的阳性表达率分别为100.00%和89.28%,在肺癌组织中的阳性表达率为54.26%,正常支气管黏膜组织与肺癌之间、肺良性病变与肺癌之间的阳性表达率差异有统计学意义(P<0.05),Maspin阳性表达率与NSCLC临床分期、淋巴结转移相关,与病理类型、组织分化程度无关。结论:Maspin在非小细胞肺癌中的表达明显下降,在肺癌发生、发展、转移过程中能发挥调控作用。
Objective： To study the expression of Maspin in human non-small cell lung cancer. Methods： A immunohistochemical method PictureTM was used to detect maspin in 94 cases of lung cancer, 54 of normal bronchial mucosas and 28 of innocent diseases. Results： Maspin expressed itself in 100.00%, 89.28%, 54.26% of normal bronchial epithelial cell, innocent disease, non- small cell lung cancer, respectively（ P 〈 0.05）. It correlated with LN（ ＋ ） and TNM staging but did not with histological type and classification degree. Conclusion： Maspin significantly decreases in NSCLC, and it may be a sensitive predictor of metastasis and prognosis for NSCLC.
出处
《山东大学学报（医学版）》
CAS
北大核心
2006年第10期1078-1080,共3页
Journal of Shandong University:Health Sciences
