摘要
目的从木立芦荟(Aloe arborescens)中寻找新的BACE(β-分泌酶)抑制活性成分。方法用硅胶正相色谱及反相色谱技术进行活性成分的分离纯化,根据理化性质、光谱资料进行结构鉴定。结果从木立芦荟95%乙醇提取物的乙酸乙酯部分和正丁醇部分,分离得到了8个化合物:异丁酰基芦荟宁A(1),芦荟宁A(2),芦荟大黄素(3),(E)-2-acetonyl-8-(2′-O-feru loxyl)-β-D-glucopyranosyl-7-m ethoxy-5-m ethyl-chromone(4),7-O-m ethyl aloeresin A(5),芦荟苷A(6),elgon ica-d im er A(7)和elgon ica-d im er B(8)。结论化合物1为新化合物,化合物4为首次从该植物中分离得到。活性测试结果表明,化合物2,4,5,6对BACE有一定的抑制活性。
Aim To seek for new components as BACE inhibitors from Aloe arborescens. Methods The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis. Results Eight compounds were isolated and their structures identified as 6＇-O-isobutyryl aloenin A （ 1 ） , aloenin A （ 2 ） , aloe-emodin （ 3 ） , （E） -2-acetonyl-8- （ 2＇-O-feruloxyl ） -β- D-glucopyranosyl-7-methoxy-5-methyl-chromone （4） , 7-O-methylaloeresin A （ 5 ） , babarloin A （ 6 ） , elgonica-dimer A （7）, and elgonica-dimer B （8）, separately. Conclusion Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.
出处
《药学学报》
CAS
CSCD
北大核心
2006年第10期1000-1003,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(20432030
30500647).
