1Setchell KD,Brown NM,Lydeking-Olsen E.The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones.J Nutr,2002,132:3577～3584.
2Decroos K,Vanhemmens S,Cattoir S,et al.Isolation and characterization of an equol-producing mixed microbial culture from a human faecal sample and its activity under gastrointestinal conditions.Arch Microbiol,2005,183:45～55.
3Selvaraj V,Zakroczymski MA,Naaz A,et al.Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice.Biol Reprod,2004,71:966～972.
4Sierens J,Hartley JA,Campbell MJ,et al.Effect of phytoestrogen and antioxidant supplementation on oxidative DNA damage assessed using the comet assay.Mutat Res,2001,485:169～176.
5Muthyala RS,Ju YH,Sheng S,et al.Equol,a natural estrogenic metabolite from soy isoflavones:convenient preparation and resolution of R-and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta.Bioorg Med Chem,2004,12:1559～1567.
6Kreijkamp-Kaspers S,Kok L,Bots ML,et al.Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women.Am J Clin Nutr,2005,81:189～195.
7Nettleton JA,Greany KA,Thomas W,et al.The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol production status but is not influenced by probiotic consumption.J Nutr,2005,135:603～608.
8Widyarini S,Husband AJ,Reeve VE.Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with a chemical cocarcinogen.Photochem Photobiol,2005,81:32～37.
9Uesugi S,Watanabe S,Ishiwata N,et al.Effects of isoflavone supplements on bone metabolic markers and climacteric symptoms in Japanese women.Biofactors,2004,22:221～228.
10Fujioka M,Uehara M,Wu J,et al.Equol,a metabolite of daidzein,inhibits bone loss in ovariectomized mice.J Nutr,2004,134:2623～2627.
6Fujimoto K,Tanaka M, Hirao Y, et al. Age-stratified serum levels of isoflavones and proportion of equol producers in Japanese end Korean healthy men[J ]. Prostate Cancer Prostatic Dis,2008,11 (3) :252 - 257.
7Setchell K. D. R, Brown N. M, Lydeking-Olesen E. The clinical importance of the metabolite equol-A due to the effectivencess of soy and its isoflavones [ J ]. Journal of Nutrition, 2002, 132 (12) :3577 - 3584.
8Ju YH,Fuhz J ,Allred KF,et al. Effects of dietary daidzein and its metabolite,equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF - 7 ) tumors implanted in ovariectomized athymic mice [ J ]. Crcinogenesis, 2006, 27(4) :856 - 863.
9HWANG J, WANG J, MORAZZONI P, et al. The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: an antioxidant mechanism for cell2 mediated LDL modification[ J ]. Free Radical Bio Med, 2003,34 (10) : 1271 - 1282.
