摘要
目的观察早期高容量血液滤过(HVHF)对多器官功能障碍综合征(MODS)及中性粒细胞(PMN)功能的影响。方法19头猪在失血性休克+内毒素双重打击后,随机分为对照组(n=9)和治疗组(HF组,n=10)。HF组在内毒素注射完后1h开始HVHF,每次滤过12h,连续3d。检测血中TNF-α、IL-1β和PMN呼吸爆发值的变化,并观察动物MODS发生率和病死率。结果HF组在HVHF治疗后血浆炎症介质浓度显著低于对照组;PMN呼吸爆发值未出现显著下降;动物MODS发生率和病死率显著低于对照组。结论早期HVHF能有效清除循环中过量的炎症介质,稳定PMN功能,改善机体免疫功能,对MODS有明显防治作用。
Objective To investigate the effects of continuous high-volume hemofiltration （HVHF） in early stage on multiple organ dysfunction syndrome （MODS） and the function of polymorphonuclear neutrophil （ PMN ） . Methods Nineteen male pigs received hemorrhagic shock and intravenous endotoxemia, and then were randomly divided into control group （n =9） and hemofiltration group （HF group, n = 10）. The pigs in HF group received HVHF （12 hours per time for 3 days） at 1 hour after infusion of endotoxin. Blood was collected to measure the plasma concentration of TNF-α, IL- 1β, and to detect the respiratory burst value of PMN by flow cytometry analysis. The morbidity and mortality of MODS in the two groups were recorded. Results Compared to control group, the concentration of inflammatory mediators were lower in the HF group, respiratory burst value of PMN didn＇t decrease significantly, and the morbidity and mortality of MODS were significantly lower. Conclusion HVHF in early stage could effectively eliminate the plasma inflammatory mediators, stablize the function of neutrophil, improve the function of immune system, and play an important role in the prevention of MODS.
出处
《中华急诊医学杂志》
CAS
CSCD
2006年第11期990-993,共4页
Chinese Journal of Emergency Medicine
关键词
多器官功能障碍综合征
高容量血液滤过
中性粒细胞
Multiple organ dysfunction syndrome
High volume hemofihration
Polymorphonuclear neutrophil
