摘要
作为生物医用材料而言,由于聚乳酸本身的缺陷,制备具有生物活性的聚乳酸就成为一条可行的弥补之道。目前聚乳酸生物活化的方法有物理法和化学法。物理法主要通过共混、表面吸附或涂层等实现对聚乳酸的生物活化;化学法包括共聚、交联、表面修饰等,通过改变聚合物大分子或表面结构赋予材料生物活性。本文对这些方法进行了评述,并提出了采用仿生性设计原则来制备具有生物活性的聚乳酸材料。
Due to the shortage of polylactic acid （PLA） as a biomedical material, the preparation of bioactive PLA becomes an effective method to compensate. At present, the methods of PLA modification to prepared bioactive PLA include physical and chemical ways. The physical ways are blending, surface adsorping or coating. The chemical ways are copolymerizing, crosslinking and surface modifying, all of which endow bioactivity on PLA by changing the polymeric macromolecule structure or surface structure. Here reviewed thcsc methods and proposed to prepare and fabricate bioactive PLA by bionic design principle.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2006年第6期28-31,216,共5页
Polymer Materials Science & Engineering
基金
国家自然科学基金资助项目(30300084)
关键词
聚乳酸
生物活性
改性
polylactic acid
bioactive
modification
