摘要
目的探讨磁场对急性心肌梗死(AMI)大鼠心肌的保护作用。方法将65只Wistar大鼠分为空白对照组、磁场对照组、AMI组、药物治疗组和磁场治疗组,药物治疗组造模后每日肌肉注射心得安,剂量为5 mg／kg体重,磁场治疗组造模后将0．09 T的磁片埋于心前区皮下。于实验第6天测定大鼠血清Mg2+、血浆MDA、cAMP、cGMP、心肌ATP含量以及心肌梗死范围等。结果磁场治疗组和药物治疗组大鼠心肌梗死面积明显小于AMI组(P<0．05);AMI组ST段偏移幅度明显大于药物治疗组和磁场治疗组(P<0．05),T波倒置出现率也明显高于药物治疗组和磁场治疗组(P<0．05);磁场治疗组和药物治疗组血清Mg2+含量、心肌ATP水平均明显高于AMI组(P<0．05或0．01);AMI组血浆MDA、cAMP和cGMP含量均明显高于磁场治疗组和药物治疗组(P<0．01)。结论磁场作用可减小AMI大鼠心肌梗死面积、ST段偏移幅度,降低T波倒置出现率,使其血浆MDA、cAMP和cGMP的含量下降,血清Mg2+含量及心肌ATP水平上升,对心肌具有保护作用,可为磁场用于临床AMI的治疗提供实验依据。
Objective To study the protective effects of a magnetic field （MF） in acute myocardial infarction （AMI） using a rat model. Methods Sixty-five Wistar rats were randomly divided into 5 groups： a control group （GI） , a MF group （G2） , an AMI group （G3） , an AMI ＋ drug （propranolol） group （G4） and an AMI ＋ MF group （ G5 ）. The concentrations of serum Mg^2 ＋ , plasma MDA, cAMP, cGMP and myocardial ATP were measured, and the AMI areas were measured on the sixth day after treatment. Results The AMI areas in the G5 and G4 rats were distinctly smaller than those in the G3 rats, while the deviance of the ST segment and the rate of T wave reverse were obviously decreased in electrocardiograms of the G5 and G4 rats. Serum Mg^2＋ and myocardium ATP in the G5 and G4 groups were significantly increased, while the concentrations of plasma MDA, cAMP and cGMP were significantly lower than those in G3. Conclusion A magnetic field has protective effects in AMI in rats, limiting the AMI area and the plasma concentrations of MDA, cAMP and cGMP, and increasing serum Mg^2＋ and myocardial ATP.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2006年第11期730-733,共4页
Chinese Journal of Physical Medicine and Rehabilitation
基金
吉林省教育厅资助课题(No 2003029)
关键词
磁场
急性心肌梗死
Magnetic fields
Acute myocardial infarction
