摘要
目的：观察FOLFOX方案以奥沙利铂联合亚叶酸钙及5氟脲嘧啶化疗对转移性结直肠癌患者细胞免疫的影响。方法：40例晚期结直肠癌患者，行奥沙利铂130mg／m^2，静脉滴注，第1天，亚叶酸钙200mg／m^2，静脉滴注，第1～5天，5氟脲嘧啶500mg／m^2，静脉滴注，第1-5天。3周为1周期。分别于化疗第1天，第7天及第14天采血查细胞免疫。结果：本组患者第1天，与第7天及第14天细胞免疫CD3^＋、CD4^＋、CD8^＋、CD4^＋／CD8^＋及NK细胞活性比较，均P〉0．05。结论：FOLFOX方案治疗转移性结直肠癌效果肯定，可改善患者生存质量，对机体免疫力影响小。
Objective： To observe effect of chemotherapy with oxaliplatin plus leucovorin/5 - fluorouracil on cellular immunity of colorectal cancer patients with metastases. Methods： Forty patients with advanced colorectal cancer were treated by FOLFOX regimen： oxaliplatin 130 mg/m^2, iv gtt dl ; leucovorin 200 mg/m^2 iv gtt d1-5 ; 5 -fluorouracil 500 mg/m^2 iv gtt d1-5. 3 weeks were a cycle. Blood samples were used to check cellular immunity on lst,7th, 14th day of chemotherapy. Results：Compared the cellular immunity CD3^＋ ,CD4^＋ ,CD8^＋ ,CD4^＋/CD8^＋ and the NK cell activity on 1 st,7th, 14th day of chemotherapy in these patients, all P 〉 0.05. Conclusion： FOLFOX regimen is effective to treat colorectal cancer patients with metastases and brings only little effect on human immunity,as well as improves the patients＇life quality.
出处
《现代肿瘤医学》
CAS
2006年第12期1577-1578,共2页
Journal of Modern Oncology
关键词
结直肠癌
转移
T细胞亚群
联合化疗
colorectal cancer
metastasis
T cell subsets
combined chemotherapy
