摘要
磷酰化氨基酸及其酯属于磷酰胺类,它们作为天然氨基酸的含磷类似物,具有良好的生物活性,它的合成与性质的研究引起人们的浓厚兴趣.本工作用亚硫酰氯先合成磷酰化酰氯,再由其与氨基酸甲酯反应合成了一系列磷酰化氨基酸酯,产物经红外光谱,核磁共振氢谱、碳谱、磷谱,质谱及元素分析鉴定,并初步研究这些化合物的抗菌与抗肿瘤的生物活性.
Phosphoryl amino acids and phosphoryl amino acid esters, as phosphorus analogs of amino acid, have attracted much attention because they show wide biological activities. In this paper, the title compounds, 2-isopropoxy-（2-isopropyl-5-methyl-cyclohexyloxy）-phosphoryl amino acid esters, were synthesized in the presence of sulfuryl chloride with reasonable yields. Their structures were confirmed by IR, ^1H NMR, ^13C NMR, 31p NMR and MS spectra, and the antibacterial and antitumor activities of these compounds were given in this paper.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2006年第12期1677-1681,共5页
Chinese Journal of Organic Chemistry
基金
福建省重点基金(No.2001F008)资助项目.
关键词
磷酰胺类衍生物
亚硫酰氯
合成
波谱表征
生物活性
phosphonaminate
sulfuryl chloride
synthesis
spectra characterization
biological activity
