摘要
目的探讨18F-脱氧葡萄糖正电子发射体层显像(18F-FDG-PET)检查在食管癌患者诊断、治疗中的应用价值。方法1999年10月~2005年12月,对52例食管癌患者行全身18F-FDG-PET检查,其中15例在检查前未经任何治疗,37例为综合治疗后复查。采用目测法结合半定量分析法判读18F-FDG-PET检查结果,并与病理检查和随访结果进行对比。结果在15例行18F-FDG-PET检查前未经任何治疗的食管癌患者中,11例患者(T2~T4)原发肿瘤显影,4例T1原发肿瘤未显影;18F-FDG-PET检查定性诊断的灵敏度为73.3%(11/15)。8例手术治疗的患者切除纵隔和腹腔直径>1cm的淋巴结16处,术前6处经18F-FDG-PET检查定性为恶性,其中5处为转移淋巴结,1处为淋巴结结核;7例患者经18F-FDG-PET检查发现有远处器官转移,不适合手术治疗。37例经综合治疗后患者复查18F-FDG-PET,发现34例有肿瘤复发和/或转移。结论18F-FDG-PET检查对食管癌原发肿瘤和局部淋巴结转移的定性诊断价值有限,但对发现远处器官转移和判断治疗效果有较大的帮助,18F-FDG-PET检查需结合其他辅助检查才能发挥其优势。
Objective To investigate the application value of fluorine-18 fluorodeoxyglucose （^18F-FDG）- positron emission tomography （PET） in patients with esophageal cancer. Methods From October 1999 to December 2005, 52 patients with esophageal cancer （15 untreated and 37 treated patients） were imaged with ^18F-FDG-PET. ^18F-FDG-PET scans were analyzed by visual method combined with semiquantitative analysis. ^18F-FDG- PET results were compared with pathological results and follow-up survey. Results There were 15 untreated patients before ^18F-FDG-PET scans, the primary tumors in 11 patients （T2 to T4 stage） were all ^18F-FDG avid and primary site in 4 patients （T1 stage） showed nothing abnormal. The sensitivity of ^18F-FDG-PET was 73.3% （11/ 15）. In diagnosing 16 resected enlarged lymph nodes beyond 1 cm in 8 operated patients. Six lymph nodes was malignant by ^18F-FDG-PET scans before operation, there were 5 metastases lymph nodes and 1 tuberculosis nodes. ^18F-FDG-PET revealed distant metastases in 7 patients and corrected them from surgery candidates to late stage. In 37 treated patients ^18F-FDG-PET confirmed 34 patients with recurrence and/or metastasis. Conclusion ^18F-FDG-PET has limited value in comfirming T and N stage in esophageal cancer. It shows much value in M stage and treatment guiding in patients with esophageal cancer.
出处
《中国胸心血管外科临床杂志》
CAS
2006年第6期393-397,共5页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
