摘要
目的：探讨溃疡愈合质量对消化性溃疡复发的影响。方法：将68例十二指肠球部溃疡合并幽门螺杆菌(H．Pylori)感染患者随机分为：试验组38例,对照组30例。2组均先给予标准3联疗法根除H．Pylori,1周后试验组,兰索拉唑30mg每日2次,联合铝碳酸镁(商品名,达喜)1000mg每日3次；对照组,兰索拉唑30mg每日2次；继续治疗4周。停药4周后观察内镜下溃疡愈合率、胃粘膜组织学改变；随访1年内溃疡复发情况。结果：停药4周后内镜下溃疡愈合率分别为,试验组94．7%,对照组80．0%,两者比较无显著性差异(P＞0．05)。组织学观察显示粘膜层厚度、腺体密度和腺管形态恢复,试验组显著优于对照组(P＜0．05)；1年内溃疡复发率,试验组2．8%,对照组25．0%,两者比较有显著性差异(P＜0．05)。结论：兰索拉唑联用铝碳酸镁能提高溃疡愈合质量,减少溃疡复发,显著优于单用兰索拉唑。
Objective： To evaluate quality of ulcer healing influence on the ulcer recurrence. Methods： 68 patients with duodenal ulcer and H. Pylori infection were randomized into study group （n 38） and control group （n= 30）. In the first week, both of the two groups received H. Pylori eradication regimen. Then the study group received lansoprazole 30mg twice a day with hydrotalcite 1000mg three times a day in 4 weeks. The control group just received lansoprazole 30mg twice a day in 4 weeks. Endoscopy and histologic examination were conducted in every patient at the end of 4weeks after medicine therapy. All the patients were followed up in 1 year. Results, The ulcer healing rate was 94.7% in the study group, and 80.0% in the control group at the end of fourth week after medicine therapy. There was no significant difference between the two groups on endoscopic ulcer healing rate （P〉0.05）. A better histologic restoration on mueosa thiekness, gland density and gland mor phology was observed in the study group（P〈0.05）. The ulcer recurrence rate was 2.8% in the study group and 25% in the control group, there was statistic difference between the 2 groups （P〈0.05）. Conclusion, In active duodenal ulcer, the treatment of lansoprazole combined with hydrotalcite can improve quality of ulcer healing, reduce the recurrence rate, which is better than the treatment with lansoprazole alone.
出处
《国际消化病杂志》
CAS
2006年第6期425-427,共3页
International Journal of Digestive Diseases
