摘要
目的 探讨不同胎龄和不同日龄新生儿血清CystatinC的变化。方法 将60例新生儿根据胎龄分为5组，其胎龄分别为～32周、～34周、～37周、～40周、〉40周，每组12例。将120例新生儿根据日龄分为6组，其日龄分别为～1d、～3d、～5d、～7d、～14d、～28d，每组20例。比较各组新生儿血清Cystatin C水平的差异。用微粒子增强免疫比浊法测定新生儿血清CystatinC水平。结果 （1）5组不同胎龄的新生儿出生时血清Cystatin C值分别为：（1．25±0．40）、（1．34±0，59）、（1．20±0．24）、（1．12±0．28）、（1．24±0．29）mg／L。差异无显著性意义（P〉0．05）。（2）6组不同日龄的新生儿血清CystatinC值分别为（1．30±0．34）、（1．28±0．42）、（1．22±0．37）、（1．29±0．37）、（1．28±0.46）、（1．18±0．35）mg／L，差异无显著性意义（P〉0．05）。结论 CystatinC在新生儿期不受胎龄和日龄的影响，可作为评价新生儿期肾小球滤过功能的指标。
Objective To investigate the dynamic changes of serum Cystatin C in neonates with different gestation age （GA） and day-age. Methods Sixty neonates were divided into 5 groups according to GA which were -32, -34, -37, -40 and 〉 40 weeks respectivdy, each group including 12 cases. One hundred and twenty neonates were divided into 6 groups according to day-age which were - 1, -3, -5, -7, - 14 and -28 days respectively, each group including 20 cases. The Cystatin C levels were compared among groups. The serum Cystatin C levels were measured with particle-enhanced immunoturbidimetry. Results The Cystatin C level of 5 groups with different GA were （ 1.25±0.40）, （ 1.34 ± 0.59）, （ 1.20 ± 0.24）, （ 1.12 ± 0.28） and （ 1.24 ± 0.29） rng/L respectively, showing significant difference among 5 groups（ P 〉 0.05）. The Cystatin C level of 6 groups with different day-age were （1.30±0.34）,（1.28±0.42）,（1.22±0.37）,（1.29±0.37）, （1.28±0.46） and （1.18±0.35） mg/L respectively. There were no significant difference among 6 groups（ P 〉 0,05）. Conclusion The serum Cystatin C level is stable, the GA and day-age have not influence upon it in neonatal stage. Cystatin C may be an index to evaluate the function of the glomerular filtration rate in neonate.
出处
《中国小儿急救医学》
CAS
2006年第6期524-525,共2页
Chinese Pediatric Emergency Medicine
基金
深圳市科技局资助项目(200405172)
