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诺维苯联合顺铂方案治疗晚期非小细胞肺癌的疗效观察

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摘要 目的评价NP方案(诺维苯+顺铂)对晚期非小细胞肺癌的疗效、临床受益和毒副作用。方法64例经病理或细胞学诊断为非小细胞肺癌患者,初治46例,复治18例,行NP方案化疗,每例2-6周期,共168个周期。结果有效率是43.8%,稳定(SD)37.5%,进展(PD)18.7%,中位进展期(TTP)6个月,中位生存期13个月,1年生存率52.6%。毒副反应主要为Ⅲ、Ⅳ度白细胞下降39.1%。结论NP方案治疗晚期非小细胞肺癌有较好的疗效,毒副反应可耐受。
出处 《宁夏医学杂志》 CAS 2006年第12期933-934,共2页 Ningxia Medical Journal
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  • 1孙燕 周际昌.临床肿瘤内科手册[M].北京:人民卫生出版社,2003.586-591.
  • 2Socinski NA.Cytotoxic chemotherapy in advanced non-small cell lung cancer:a review of standard treatment paradigms[J].Clin Cancer Res,2004,10(12 pt 2):421-424.
  • 3Depierre A,Le Chevalier T,Gil Deza E,et al.Vinorelbine versus vinorelbine plus cisplatin in advanced non-small cell lung cancer:a randomized trial[J].Ann Oncol,1994,5:37-42.
  • 4Wozniak AJ,Crowley JJ,Balcerzak S P,et al.Randomized trial comparing cisplatin plus vinorelbine in the treatment of advanced non-small cell lung cancer:a southwest oncology sroup study[J].J Clin Oncol.1989,16(7):2459-2465.
  • 5Hotta K,Matsuo K,Ueoka H,et al.Addition of platinum compounds to a new agent in patients with advanced non-small cell lung cancer:a literature based meta-analysis of randomised trails[J].Ann Oncol,2004,15(12):1782-1789.
  • 6张湘茹,孙燕,孔维红,周生余,冯奉仪.去甲长春花碱加顺铂治疗晚期非小细胞肺癌42例[J].中华肿瘤杂志,1998,20(1):60-62. 被引量:527
  • 7Gridelli C,Gallo C,Shepherd FA,et al.gemcitabine plus vinorelbine compared with cisplatin plus vinorelbine or cisplatin plus gemcitabine for advanced non-small cell lung cancer:a phase Ⅲ trial of the Italian GEMVIN investigators and National Cancer Institute of Canada clinical trial group[J].J Clin Oncol,2003,21(16):3025-3034.
  • 8张桂芳,慕竹青,田国防,段仁慧,王天义.NP方案联合化疗治疗晚期非小细胞肺癌疗效观察[J].现代肿瘤医学,2005,13(1):101-102. 被引量:3
  • 9Scagliotti GV,De Marinis F,Rinaldi M,et al.Phase Ⅲ randomized trial comparing three platinum-based dublets in advanced non-small cell lung cancer[J].J Clin Oncol,2002,20(21):4285-4291.
  • 10Fossella F,Pereira JR,Von Pawel J,et al.Randomized,multinational,phaseⅢ study of docetaxel plus platiunm combinations versus vinorelbine plus cisplatin for advanced non-small cell lung cancer:the TAX326 study group[J].J Clin Oncol,2003,21(16):3016-3024.

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