摘要
本研究用随机、单盲、组间、平行对照的方法，用新一代血管紧张素转换酶抑制剂赖诺普利对高血压病患者进行为期４周的治疗观察，并与另一种血管紧张素转换酶抑制剂依那普利进行对比。赖诺普利剂量为１０～８０ｍｇ／ｄ；依那普利为５～４０ｍｇ／ｄ，每天１次服用。通过２２５例的观察显示两药的降压有效率无明显差异，但赖诺普利控制２４小时的血压明显较依那普利为优，不良反应的发生率赖诺普利较依那普利为少。咳嗽的发生率两药相仿。赖诺普利有效病例的平均剂量为３４．１ｍｇ／ｄ，故建议常用剂量为１０～４０ｍｇ／ｄ，每日早餐后服用。研究证实赖诺普利是一安全、有效的降压药。
Thisrandomized,single-blinded,paralelstudyassesedtheeficacyofACEI,lisino-prilafter4weekstreatmentinhypertensivepatientsandcomparedwiththatofenalapril.Thedailydoseoflisinoprilwas10mgto80mg,andwas5mgto40mgwithenalapril.Bothdrugsweregivenoncedaily.Analysisof225patients(112patientsinlisinoprilgroup,113patientsinenalaprilgroup)revealedthatbothdrugshadsameefectsonbloodpresurereduction,whilelisinoprilwasobviouslybeterthanenalaprilincontroling24-hourbloodpressure.Alowerincidenceofadverseef-fectswasobservedinlisinoprilgroup.Cough,themostfrequentadverseefect,occuredsimilarlyinbothdrugs.Theaveragedoseoflisinoprilinresponsecaseswas34.1mgdaily.Therecommendeddoseof10to40mgoncedailywilbeappropriate.Thisstudyverifiedthatlisinoprilisasafeandefectiveantihypertensiveagent.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1996年第4期269-271,共3页
Chinese Journal of Cardiology
