期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PJ34对帕金森病模型小鼠黑质多巴胺能神经元保护的实验研究 被引量：2

在线阅读 下载PDF
导出
摘要 目的研究多聚ADP-核糖聚合酶(PARP)抑制剂PJ34对帕金森病(PD)小鼠黑质多巴胺(DA)能神经元的保护作用。方法采用1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)制备PD小鼠模型,2、24、72 h后取中脑组织进行酪氨酸羟化酶(TH)观察DA能神经元的损害情况,同时应用多聚ADP核糖聚合物(PAR)免疫组化染色检测PARP的活性改变。另经PJ34预处理该模型后,对上述指标进行检测。结果PD小鼠黑质DA能神经元出现一过性PARP的过度活化,PJ34预处理显著抑制PARP活性,减轻PD小鼠黑质致密部TH阳性神经元的脱失现象(P<0.01)。结论PARP的活性改变在PD的发病过程发挥重要作用,PJ34通过抑制PARP过度活化对PD小鼠黑质DA能神经元产生保护作用。
作者 王东玉 商秀丽 张朝东
机构地区 中国医科大学附属第一临床学院神经内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2006年第12期1688-1690,共3页 Chinese Journal of Gerontology
关键词 帕金森病 1-甲基-4-苯基-1 2 3 6-四氢吡啶 多聚ADP-核糖聚合酶 PJ34
分类号 R742.5 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献15

  • 1陈生弟.我国帕金森病的研究进展(述评)[J].中国神经免疫学和神经病学杂志,2001,8(2):67-69. 被引量：12
  • 2Xiao CY,Chen M,Zsengellér Z,et al.Poly (ADP-Ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor[J].J Phar Exp Ther Fast Forw,2004 ;310:498-504.
  • 3Komjati K,Mabley J,Virag L,et al.Poly(ADP-ribose) polymerase inhibitor protects neurons and white matter and regulates the apoptosis-inducing factor translocation in stroke[J].Int J Mol Med,2004 ;13:373-82.
  • 4Sedelis M,Hofele K,Auburger GW,et al.MPTP susceptibility in the mouse:behavioral,neurochemical,and histological analysis of gender and strain differences[J].Behav Genet,2000 ;30 (3):171-82.
  • 5Kauppinen TM,Swanson RA.Poly (ADP-ribose) polymerase-1 promotes microglial activation,proliferation,and matrix metalloproteinase-9-mediated neuron death[J].J Immunol,2005;174(4):2288-96.
  • 6Herceg Z,Wang ZQ.Functions of poly(ADP-ribose) polymerase (PARP)in DNA repair,genomic integrity and cell death[J].Mutat Res,2001 ;477(1-2):97-110.
  • 7Smith S.The world according to PARP[J].Trends Biochem Sci,2001 ;26(3):174-9.
  • 8Koh DW,Dawson TM,Dawson VL.Mediation of cell death by poly(ADP-ribose) polymerase-1[J].Pharmacol Res,2005 ;52 (1):5-14.
  • 9王东玉,张朝东.多聚ADP核糖聚合酶与帕金森病关系的研究进展[J].国外医学（老年医学分册）,2005,26(5):208-211. 被引量：4
  • 10Mandir AS,Przedborski S,Jackson-Lewis V,et al.Poly (ADP-ribose)polymerase activation mediates 1 -methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-induced parkinsonism[J].Proc Natl Acad Sci USA,1999 ;96(10):5774-9.

二级参考文献23

  • 1Vila M,Lewis VJ,Vukosavic S,et al.Bax ablation prevents dopaminergic neurodegeneration in the l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.Proc Notl Acad Sci USA 2001; 98(5):2837-42
  • 2Tatton NA,Kish S.J.In situ detection of apoptosis nuclei in the substantia nigro compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl tranderase labeling and acridine orange staining.Neuroscience 1997; 77(4
  • 3Mukherjee SK,Klaidman LK,Yasharel R,et al.Increased brain NAD prevents neuronal apoptosis in vivo.Eur J Pharmacology 1997; 330:27-34
  • 4Cosi C,Colpaert F,Wouter K,et al.Poly(ADP-ribose)polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57BL/6 mice.Brain Res 1996; 729:264-91
  • 5Jean-Christophe Am e, Spenlehauer C, Gilbert de Murcia.The PARP superfamily. Bio Essays, 2004; 26; 882-893.
  • 6Burkle A, Diefenbach J, Brabeck C et al. Ageing and PARP. Pharmacol Res, 2005; 52 (1): 93-99.
  • 7Komjati K, Besson VC, Szabo C. Poly (ADP-ribose)polymerase inhibitors as potential therapeutic agents in stroke and neurotrauma. Curr Drug Targets CNS Neurol Disord, 2005; 4 (2): 179-194.
  • 8Burkle A, Brabeck C, Diefenbach J et al. The emerging role of poly (ADP-ribose) polymerase-1 in longevity. Int J Biochem Cell Biol, 2005; 37 (5): 1043-1053.
  • 9Nguewa PA, Fuertes MA, Valladares B et al. Poly (ADP-ribose) polymerases: hornolcgy, structural domains and functions. Novel therapeutical applications. Prog Biophys Mol Biol, 2005; 88 (1): 143-172.
  • 10Gilliams-Francis KL, Quaye AA, Naegele JR. PARP cleavage, DNA fragmentation, and pyknosis during excitotoxin-induced neruonal death. Exp Neurol, 2003; 184(1) : 359- 372.

共引文献16

同被引文献23

  • 1王东玉,张朝东.多聚ADP核糖聚合酶与帕金森病关系的研究进展[J].国外医学（老年医学分册）,2005,26(5):208-211. 被引量：4
  • 2王东玉,张朝东.多聚ADP-核糖聚合酶抑制剂对帕金森病小鼠相关脑区病理变化的影响[J].解剖科学进展,2006,12(4):307-310. 被引量：2
  • 3Zhang D, Zhang J J, Liu GT.The novel squamosamide derivative FLZ protects against 6-hydroxydopamine-induced apoptosis through inhibition of related signal transduction in SH-SY5Y cells[J].Eur J Pharmaco, 2007, 561(1-3):1-6.
  • 4Chu CT, Zhu JH, Cao G, et al. Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells[J]. J Neurochem,2005,94(6): 1685-1695.
  • 5Arai N, Misugi K, Goshima Y, et al. Evaluation of a 1-methyl-4- phenyl-1, 2, 3, 6- tetrahydropyridine (MPTP)-treated C57 black mouse model for parkinsonism[J]. Brain Res, 1990, 515: 57-63.
  • 6Xiao CY, Chen M, Zsengeller Z, et al. Poly (ADP-ribose) polymerase promotes cardiac remodeling contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure[J]. J Pharmacol Exp Ther, 2005, 312:891- 898.
  • 7Cregan SP, Fortin A, MacLaurin JG, et al. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death[J]. J Cell Biol, 2002,158(3):507-517.
  • 8Cho BB, Toledo-Pereyra LH.Caspase-independent programmed cell death following ischemic stroke[J]. J Invest Surg, 2008, 21(3): 141- 147.
  • 9Wang H, Shimoji M, Yu SW, et al. Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease[J]. Ann N Y Acad Sci, 2003, 991: 132-139.
  • 10Komjati K, Mabley JG, Virag L, et al. Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke[J]. Int J Mol Med,200d, 13(3):373-382.

引证文献2

二级引证文献2

中国老年学杂志
2006年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部