摘要
目的:探讨乳腺癌P53蛋白的表达临床意义。方法:应用免疫组织化学方法检测79例乳腺癌中P53蛋白的表达,分析P53蛋白表达与乳腺癌临床病理因素及淋巴结转移的相关性。结果:乳腺癌P53阳性率为46.84%,其表达与组织学分级、ER表达有相关性(P<0.01),而与患者年龄、肿瘤长径、TNM分期、病理学类型无关(P>0.05)。P53蛋白在乳腺癌中表达与淋巴结转移呈正相关(P<0.01)。单因素生存分析乳腺癌P53蛋白表达是影响其预后的因素(P<0.05)。多因素生存分析乳腺癌P53蛋白表达独立的预后因素(P<0.05)。结论:乳腺癌P53蛋白表达与淋巴结转移单、多因素生存分析是影响预后的重要因素。
Objective： To investigate the clinicopathologic significance of P53 protein in breast carcinoma and the association of the expression of P53 protein with nodal involvement, and to evaluate their prognostic values. Methods：The expression of P53 protein in 79 breast carcinomas was measured by immunohistochemical method. The relation to the clinicopathologic features was analyzed. Results： The positive rate of P53 protein expression in breast carcinoma was 46.84%, and was only associated with differentiated Grade and ER status （P〈0.01） among the clinicopathologic features. There was positive correlation between expression of P53 protein and nodal involvement （P〈0.01）. The Univariate analysis showed that P53 was a significant individual prognostic variable. Multivariate analysis showed that P53 also was an independent prognostic factor statistically. Conclusions： The positive rate of P53 protein expression in breast carcinoma was associated with nodal involvement. The Univariate and Multivariate analysis showed that P53 was an important independent prognostic factor statistically.
出处
《交通医学》
2006年第6期658-659,664,共3页
Medical Journal of Communications
关键词
乳腺癌
P53蛋白
转移
预后
breast carcinoma
P53 protein
nodal involvement
Prognosis
