摘要
目的观察乌司他丁治疗多器官功能障碍综合征的临床疗效。方法82例多器官功能障碍综合征患者随机分为两组,对照组40例,采用常规治疗;治疗组42例,在常规治疗的基础上加用静脉注射乌司他丁。观察两组治疗前后血清肿瘤坏死因子、白细胞介素-1、白细胞介素-6的水平。结果治疗组血清肿瘤坏死因子、白细胞介素-1、白细胞介素-6下降均显著优于对照组(P<0.05),治疗组住ICU的时间也比对照组明显缩短(P<0.01)。结论乌司他丁治疗多器官功能障碍综合征疗效较好,可用于多器官功能障碍综合征的治疗。
Objective To observe the clinical effect of ulinastatin （UTI） in treating muhiorgan dysfunction syndromes （MODS）. Methods Eighty-two patients with MODS were randomly divided into two groups. Forty cases in the control group were treated with normal medicine. Forty-two cases in UTI group were treated with normal therapy in combination with UTI through intravenous injection. Two groups were compared on the levels of serum tumor necrosis-a （ TNF-a）, interleukins-1 （ IL-1 ） and IL-6 before and after the treatment. Results The levels of TNF-a, IL-1 and IL-6 in UTI group were significantly lower than those in the control group （ P 〈 0. 05 ）. Moreover, there was obvious difference between two groups in the total time in ICU （ P 〈0.01 ）. Conclusion UTI are effective on MDS patients, and can be used in the treatment of MODS.
出处
《广东药学院学报》
CAS
2006年第6期672-674,共3页
Academic Journal of Guangdong College of Pharmacy
