摘要
目的探讨抑肽酶对手术应激后猪内分泌激素及细胞因子的影响。方法26只肝移植供体猪随机分为抑肽酶组与对照组,每组13只。抑肽酶组在气管插管前静注200万KIU抑肽酶,50万KIU/h术中维持。在气管插管前、开腹前、开腹后30min、全身肝素化前对静脉血中的促肾上腺皮质激素(ACTH)、皮质醇(COR)、胰高血糖素以及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的浓度进行测定。结果气管插管前各项指标无差异,随着手术的进展ACTH、COR、胰高血糖素、IL-6的浓度抑肽酶组均明显低于对照组(P＜0．05),TNF-α值两组无差异(P＞0．05)。结论抑肽酶的应用能减轻机体创伤后应激激素与部分细胞因子的释放,有利于内环境的稳定。
Objective To observe the effect of aprotinin on stress hormone and cytoldne during operation in pig. Methods 26 pig undergoing liver transplantation donator surgery were randomly divided into two groups（ n = 13 ）： aprotinin group and control group. Aprotinin were administrated 2000000KIU iv before tracheal intubation, and 500000KIU/h iv gtt during operation in aprotinin group. The contents of adrenocorticotrophic hormone （ACTH）, corticosteriod （COR）, glucagon, interleukin- 6 （IL-6） and tumor necrosis factor （TNF） were measured and analyzed at following points： before tracheal intubation; before surgery starting; 30min after surgery starting; before heporinization. Results Plesma levels of the above - mentioned were not different between two groups, while, at later various times ACTH, COR, glucngon, IL- 6 in aprotinin group were significantly lower than those in control group（ P 〈 0.05）.The contents of TNF were not different between two groups. Conclusion Aprotinin may decrease releasing of stress hormone and cytokine after trauma and stabilize inner circumstance.
出处
《中国热带医学》
CAS
2007年第1期79-81,共3页
China Tropical Medicine
