摘要
生物制造工程是快速成形与生物材料、生物医学相互融合形成的新兴交叉学科。生物材料喷射技术是生物制造工程核心技术之一。在实际应用的基础上,研究了螺杆挤压喷射、活塞挤压喷射、气动挤压喷射、微滴喷射技术、激光引导直写技术和电纺丝技术、蘸笔纳米刻蚀技术的原理、使用范围和优缺点,并介绍了国内外相关技术的最新进展。喷头的选取在一定程度上决定了支架的成形精度和复杂程度．可以通过对不同喷射技术的出丝直径、成形效率和适合材料比较,来选择合适的喷射技术。生物制造中喷射技术的发展主要有四个方向：在满足一定成形精度的要求下,尽量扩展喷射技术的材料使用范围：在一定的材料应用范围内,尽量提高精度；追求喷射技术精度在量级上的提高；尽量减少在喷射过程中对材料的影响。
Bio-manufacturing is an interdisciplinary research area, which is based on the development of rapid prototyping technology, biomaterials and biomedical technology. The jetting techniquc for biomaterial is one of the key factors in bio-manufacturing engineering. The principle, using range, advantages and disadvantages of the jetting techniques such as screw extrusion, piston extrusion, pneumatic extrusion, micro-droplet, laser-guided direct writing, electrostatic spinning and DPN are researched, on the basis of practical applications. The new progress of those technologies also is introduced. The scaffold shaping accuracy and complex degree are partly decided by the choice of nozzle. The right jetting technology is selected by the comparison of microroplet diameter, assembly efficiency and using biomaterials. The developing trend fits into the following four directions： fitting more board biomaterials based on filling the required precision, heightening of shaping precision in the range of application biomaterials, improving the order of magnitude in precision and reducing effect on the biomaterials.
出处
《机械工程学报》
EI
CAS
CSCD
北大核心
2006年第12期13-20,共8页
Journal of Mechanical Engineering
基金
国家自然科学基金(50105008)
博士点基金(20050003046)资助项目。
关键词
快速成形
生物制造
微滴喷射
Rapid prototyping Bio-manufacture Micro-droplet
