摘要
目的:构建以证候为内容的原发性肝癌中医疗效评价体系,并验证其可靠性。方法:在原发性肝癌中医常见基本证候轻重程度量化评价研究的基础上,以100mm刻度法及综合评价层次分析法(analytichierarchyprocess,AHP)为数学工具,以“综合集成研讨厅”为重要研讨方式,共取57个中医症状为底层指标,以8个基本证候及实证、虚证为第二层、第三层次指标,以证候总评价为顶层指标,构建以证候为内容的原发性肝癌综合疗效评价体系,并在临床上与西医的肿瘤轻重程度评分、卡氏评分、肿瘤分期、Child分级及生存质量等进行相关性对比研究,对模型的可靠性进行验证。结果:成功地构建了以证候为内容的原发性肝癌中医疗效评价体系。通过与西医指标的对比研究,发现证候总评分能够反映肿瘤进展情况、患者肝功能变化及以卡氏评分表达的患者体质状况;证候总评分与患者生存质量有较强相关性。结论:构建的以证候为内容的原发性肝癌中医疗效评价体系,能够反映疾病轻重程度,并能体现中医治疗目标与结果的相关性。
Objective： To construct a system of therapeutic effect evaluation for patients with primary liver cancer according to the theory of syndrome differentiation in traditional Chinese medicine （TCM）, and to examine its reliability.
Methods： Analytic hierarchy process and 100 mm surveyors rod method were applied to obtain bottom layer and top level syndromes, which were used to construct the method of therapeutic effect evaluation, and its reliability was verified in clinical practice by comparing with some evaluation criteria in Western medicine, such as cancer severity scale; Karnofsky performance scale; Child-Pugh classification, cancer staging classification, and quality of life scale, etc.
Results： A system of therapeutic effect evaluation was constructed, and it could reflect the progress of tumor, changes of hepatic function and constitution. The evaluation scores acquired from the system were highly associated with the quality of life of the patients.
Conclusion： The system of therapeutic effect evaluation can reflect the severity of disease and the characteristics of TCM treatment.
出处
《中西医结合学报》
CAS
2007年第1期15-22,共8页
Journal of Chinese Integrative Medicine
基金
上海市科学技术委员会基础研究资助项目(No.05JC14044)
国家自然科学基金资助项目(No.90209018)
关键词
肝癌
中医药
疗效评价
层次分析法
证候
liver cancer
traditional Chinese medicine
curative effect evaluation
analytic hierarchy process
syndrome
