摘要
随着基因工程技术的飞速发展,转基因小鼠模型对研究肿瘤基因特征、肿瘤抑制基因的表达和功能有着重要的作用。近年来,肿瘤血管生成理论成为肿瘤研究的新热点。与肿瘤血管生成相关的调控基因的研究也越来越受到重视。该文对转基因小鼠模型在肿瘤研究中的进展作了综述,并着重介绍了关于肿瘤血管生成调控基因转基因小鼠模型的研究情况。
With the development of recombinant DNA technology, genetically altered mouse models for human cancers are critical to the investigation and characterization of oncogene and tumor suppressor gene expression and function and the associated cancer phenotype. Recently, the inhibition of tumor angiogenesis becomes a new ＂hot spot＂ in cancer researches. And the genes involved in the regulation of tumor angiogenesis play an increasingly important role in the field of tumor researches. This review is about the progress of the research in transgenic tumor models and focuses on genes regulating tumor angiogenesis associated with transgenic mice model.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2007年第1期4-8,共5页
Chinese Pharmacological Bulletin
基金
中国药科大学校级青年科研基金资助项目
