摘要
目的探讨中药复方降糖灵对糖尿病大鼠的血糖和血脂代谢的作用。方法用灌喂脂肪乳剂4周后,腹腔注射0.2%链脲佐菌素(STZ)30 mg/kg的方法造成大鼠糖尿病模型后,用含生药量1 g/m l的降糖灵灌胃进行治疗,并同时用二甲双胍按1 mg/kg灌胃作为阳性药物治疗,1次/d,连续6周。实验结束后观察降糖灵和二甲双胍对大鼠体重、血浆胰岛素、蛋白组成和含量变化、血脂含量和组成变化以及肝糖原的含量变化等。结果各组大鼠的体重变化差异不大(P>0.05),二甲双胍和降糖灵能明显降低糖尿病大鼠的血糖。二甲双胍能降低胆固醇的含量,但是不能增加高密度脂蛋白、白蛋白、血浆胰岛素和肝糖原的含量。降糖灵可将升高高密度脂蛋白、白蛋白、血浆胰岛素和肝糖原的含量,同时能降低胆固醇和甘油三酯的含量(P<0.05)。结论降糖灵组能有效地降低高脂高糖大鼠的血糖和血脂,其作用机制可能与其促进胰岛释放胰岛素、增加肝糖原的合成和改善脂代谢有关。
Objective To study the effects of Jiang - Tang - Ling on glucose and lipid metabolism in diabetic rats. Methods Rats were fed with high sugar and fat food for 4 weeks, then 0. 2% streptozotocin （STZ ,30 mg/kg^-1） was injected intraperitoneally to induce hyperglycemia and hyperlipemla. The model rats were administrated with Jiang - Tang - Ling（ 1 g/ml） or metformin（1 mg/kg）, once a day for 6 weeks. After the experiment, the body weight, the blood glucose, the plasma llpids, the plasma albumen,insulin, and liver hepatin were observed. Results The body weight had no difference among the groups（P 〉 0. 05 ）. Jiang - Tang - Ling and mefformin decreased the blood sugar and cholesterin, Jiang - Tang - Ling also increased HDL - C, albumin, plasma insulin and liver hepatin, and decreased plasma triacyl glycerol（ P 〈 0. 05 ）. Conclusion Jiang- TangLing can adjust the blood glucose and lipid effectively, and the mechanism maybe related to enhancc the insulin release, increase liver glycogen synthesis and improve lipids metabolism.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第1期9-11,共3页
Lishizhen Medicine and Materia Medica Research
基金
广东省科技计划资助项目(No.2003C30501)
