摘要
目前,4个种衣原体:豚鼠嗜性衣原体、鼠衣原体、沙眼衣原体和肺炎嗜性衣原体基因组已有较详细的研究,揭示了衣原体基因组的紧密性和多成员的起因。多形态膜蛋白多基因家族、具有第Ⅲ型分泌系统功能基因以及编码肽聚糖基因的发现,反映了该领域的重要研究成果。随着多个种株衣原体基因组完整核苷酸序列测定的完成,人们对衣原体发育过程中生产合成的多种蛋白的认识也在不断深入,主要包括外膜蛋白、外膜主蛋白、热休克蛋白、多态外膜蛋白等,这些蛋白的结构和功能不同,充分认识其特性对衣原体的致病机理、免疫发生机理的研究及高效基因工程疫苗的研制将会产生重要的影响。
Following genomes from various strains of Chlamydia spp being sequenced, it was found that there were only tiny changes in their gene components, the infected host variety and pathogenisis process were very different. The genomes from Chlamydia trachomatis, C. muridarum, C . pneumoniae, Chlamydophila caviae were studied in detail, which revealed the relationship of chlamydial genomes and multiple members causes. The discovery of polymorphic membrane protein gene family, type Ⅲ secretion gene and peptidoglycan coding gene showed the great research success in the field. After the complete nucleotide acids of various species and strains of Chlamydia spp were sequenced many proteins were further identified, involving the outer membrane protein, major outer membrane protein, hot shock protein and polymorphic membrane protein with different functions and structures. Fully understanding＇ the properties of these proteins is in favor of studying mechanisms of pathogenisis and immunity of Chlamydia as well as high-effective gene engineering vaccine against chlamydiosis.
出处
《基础医学与临床》
CSCD
北大核心
2007年第1期94-99,共6页
Basic and Clinical Medicine
基金
国家高技术研究发展计划(863计划)(2003AA241110)
关键词
衣原体
基因组
结构蛋白
Chlamydia spp
genome
structural proteins
